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An Adaptive Physiologically Based Pharmacokinetic-Driven Design to Investigate the Effect of Itraconazole and Rifampicin on the Pharmacokinetics of Molibresib (GSK525762) in Healthy Female Volunteers.
Riddell, Kylie; Patel, Aarti; Collins, Gary; Zhou, Yanyan; Schramek, Dan; Kremer, Brandon E; Ferron-Brady, Geraldine.
Affiliation
  • Riddell K; GlaxoSmithKline Research and Development, Ermington, NSW, Australia.
  • Patel A; Drug Metabolism and Pharmacokinetics, GlaxoSmithKline R&D, Ware, UK.
  • Collins G; Drug Metabolism and Pharmacokinetics, GlaxoSmithKline R&D, Ware, UK.
  • Zhou Y; Biometrics, GlaxoSmithKline, Collegeville, Pennsylvania, USA.
  • Schramek D; Clinical Programming, GlaxoSmithKline, Collegeville, Pennsylvania, USA.
  • Kremer BE; Research and Development Oncology, GlaxoSmithKline, Collegeville, Pennsylvania, USA.
  • Ferron-Brady G; Clinical Pharmacology Modeling and Simulation, GlaxoSmithKline, Collegeville, Pennsylvania, USA.
J Clin Pharmacol ; 61(1): 125-137, 2021 01.
Article in En | MEDLINE | ID: mdl-32820548
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Rifampin / Benzodiazepines / Itraconazole / Cytochrome P-450 CYP3A Inducers / Cytochrome P-450 CYP3A Inhibitors Type of study: Clinical_trials / Guideline / Prognostic_studies Limits: Adult / Female / Humans / Middle aged Language: En Journal: J Clin Pharmacol Year: 2021 Document type: Article Affiliation country: Australia Country of publication: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Rifampin / Benzodiazepines / Itraconazole / Cytochrome P-450 CYP3A Inducers / Cytochrome P-450 CYP3A Inhibitors Type of study: Clinical_trials / Guideline / Prognostic_studies Limits: Adult / Female / Humans / Middle aged Language: En Journal: J Clin Pharmacol Year: 2021 Document type: Article Affiliation country: Australia Country of publication: United kingdom