Viroinformatics approach to explore the inhibitory mechanism of existing drugs repurposed to fight against COVID-19.

Bibi, Nousheen; Gul, Sana; Ali, Johar; Kamal, Mohammad Amjad

Bibi, Nousheen; Gul, Sana; Ali, Johar; Kamal, Mohammad Amjad.

Affiliation

Bibi N; Department of Bioinformatics, Shaheed Benazir Bhutto Women University, Peshawar, Pakistan. Electronic address: biogomal@gmail.com.
Gul S; Department of Bioinformatics, Shaheed Benazir Bhutto Women University, Peshawar, Pakistan.
Ali J; Center for Genomics Sciences Rehman Medical Institute, Peshawar, Pakistan.
Kamal MA; King Fahd Medical Research Center, King Abdulaziz University, Jeddah, 21589, Saudi Arabia; Enzymoics, 7 Peterlee Place, Hebersham, NSW, 2770, Australia; Novel Global Community Educational Foundation, Australia.

Eur J Pharmacol ; 885: 173496, 2020 Oct 15.

Article in En | MEDLINE | ID: mdl-32841640

Subject(s)

Computational Biology; Coronavirus Infections/drug therapy; Drug Repositioning; Pneumonia, Viral/drug therapy; Amino Acid Sequence; Angiotensin-Converting Enzyme 2; COVID-19; Coronavirus Infections/metabolism; Humans; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Targeted Therapy; Pandemics; Peptidyl-Dipeptidase A/chemistry; Peptidyl-Dipeptidase A/metabolism; Pneumonia, Viral/metabolism; Protein Structure, Tertiary; RNA-Dependent RNA Polymerase/chemistry; RNA-Dependent RNA Polymerase/metabolism; Spike Glycoprotein, Coronavirus/chemistry; Spike Glycoprotein, Coronavirus/metabolism

Key words

ACE2; COVID-19; Drug repurposition; Molecular docking; Molecular dynamics simulations; RdRp; Spike protein

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Computational Biology / Drug Repositioning Limits: Humans Language: En Journal: Eur J Pharmacol Year: 2020 Document type: Article Country of publication: Netherlands

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google