Nef homodimers down-regulate SERINC5 by AP-2-mediated endocytosis to promote HIV-1 infectivity.

Staudt, Ryan P; Smithgall, Thomas E

Staudt, Ryan P; Smithgall, Thomas E.

Affiliation

Staudt RP; Department of Microbiology and Molecular Genetics, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA.
Smithgall TE; Department of Microbiology and Molecular Genetics, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA. Electronic address: tsmithga@pitt.edu.

J Biol Chem ; 295(46): 15540-15552, 2020 11 13.

Article in En | MEDLINE | ID: mdl-32873704

Subject(s)

HIV-1/physiology; Membrane Proteins/metabolism; Transcription Factor AP-2/metabolism; nef Gene Products, Human Immunodeficiency Virus/metabolism; Dimerization; Down-Regulation; Endocytosis; Endosomes/metabolism; HEK293 Cells; HIV Infections/metabolism; HIV Infections/pathology; HIV-1/metabolism; Humans; Jurkat Cells; Membrane Proteins/antagonists & inhibitors; Membrane Proteins/genetics; Mutagenesis, Site-Directed; Transcription Factor AP-2/chemistry; Transcription Factor AP-2/genetics; Virus Internalization; nef Gene Products, Human Immunodeficiency Virus/chemistry; nef Gene Products, Human Immunodeficiency Virus/genetics

Key words

HIV-1 Nef; SERINC5; adaptor protein complex 2; bimolecular fluorescence complementation (BiFC); dimerization; endocytosis; human immunodeficiency virus (HIV); infectious disease; infectivity; proteinprotein interaction; restriction factor

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HIV-1 / Transcription Factor AP-2 / Nef Gene Products, Human Immunodeficiency Virus / Membrane Proteins Limits: Humans Language: En Journal: J Biol Chem Year: 2020 Document type: Article Affiliation country: United States Country of publication: United States

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