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Corticospinal tract involvement in spinocerebellar ataxia type 3: a diffusion tensor imaging study.
Inada, Bruno Shigueo Yonekura; Rezende, Thiago Junqueira Ribeiro; Pereira, Fernando Vieira; Garcia, Lucas Ávila Lessa; da Rocha, Antônio José; Neto, Pedro Braga; Barsottini, Orlando Graziani Povoas; França, Marcondes Cavalcante; Pedroso, José Luiz.
Affiliation
  • Inada BSY; Division of General Neurology and Ataxia Unit, Department of Neurology, Federal University of São Paulo (UNIFESP), São Paulo, Brazil. brunosy.inada@gmail.com.
  • Rezende TJR; Department of Neuroradiology, Hospital Beneficência Portuguesa, São Paulo, Brazil. brunosy.inada@gmail.com.
  • Pereira FV; Department of Neurology, State University of Campinas (UNICAMP), São Paulo, Brazil.
  • Garcia LÁL; Division of General Neurology and Ataxia Unit, Department of Neurology, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
  • da Rocha AJ; Department of Neuroradiology, University of São Paulo (USP), São Paulo, Brazil.
  • Neto PB; Department of Neuroradiology, Santa Casa de São Paulo School of Medical Sciences, São Paulo, Brazil.
  • Barsottini OGP; Department of Clinical Medicine, Universidade Federal do Ceará, Ceará, Brazil.
  • França MC; Center of Health Sciences, Universidade Estadual do Ceará, Ceará, Brazil.
  • Pedroso JL; Division of General Neurology and Ataxia Unit, Department of Neurology, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
Neuroradiology ; 63(2): 217-224, 2021 Feb.
Article in En | MEDLINE | ID: mdl-32876704
PURPOSE: The aim of this study was to evaluate the integrity of the corticospinal tracts (CST) in patients with SCA3 and age- and gender-matched healthy control subjects using diffusion tensor imaging (DTI). We also looked at the clinical correlates of such diffusivity abnormalities. METHODS: We assessed 2 cohorts from different Brazilian centers: cohort 1 (n = 29) scanned in a 1.5 T magnet and cohort 2 (n = 91) scanned in a 3.0 T magnet. We used Pearson's coefficients to assess the correlation of CST DTI parameters and ataxia severity (expressed by SARA scores). RESULTS: Two different results were obtained. Cohort 1 showed no significant between-group differences in DTI parameters. Cohort 2 showed significant between-group differences in the FA values in the bilateral precentral gyri (p < 0.001), bilateral superior corona radiata (p < 0.001), bilateral posterior limb of the internal capsule (p < 0.001), bilateral cerebral peduncle (p < 0.001), and bilateral basis pontis (p < 0.001). There was moderate correlation between CST diffusivity parameters and SARA scores in cohort 2 (Pearson correlation coefficient: 0.40-0.59). CONCLUSION: DTI particularly at 3 T is able to uncover and quantify CST damage in SCA3. Moreover, CST microstructural damage may contribute with ataxia severity in the disease.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyramidal Tracts / Machado-Joseph Disease / White Matter Limits: Humans Language: En Journal: Neuroradiology Year: 2021 Document type: Article Affiliation country: Brazil Country of publication: Germany

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyramidal Tracts / Machado-Joseph Disease / White Matter Limits: Humans Language: En Journal: Neuroradiology Year: 2021 Document type: Article Affiliation country: Brazil Country of publication: Germany