Structure-activity relationship studies of indolin-2-one derivatives as vascular endothelial growth factor receptor inhibitors and anticancer agents.

Yousefian, Mozhdeh; Ghodsi, Razieh

Yousefian, Mozhdeh; Ghodsi, Razieh.

Affiliation

Yousefian M; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Ghodsi R; Department of Medicinal Chemistry, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

Arch Pharm (Weinheim) ; 353(12): e2000022, 2020 Dec.

Article in En | MEDLINE | ID: mdl-32885522

Subject(s)

Angiogenesis Inhibitors/pharmacology; Indoles/pharmacology; Neoplasms/drug therapy; Neovascularization, Pathologic; Protein Kinase Inhibitors/pharmacology; Receptors, Vascular Endothelial Growth Factor/antagonists & inhibitors; Sunitinib/pharmacology; Angiogenesis Inhibitors/chemical synthesis; Animals; Humans; Indoles/chemical synthesis; Molecular Structure; Neoplasms/enzymology; Neoplasms/pathology; Protein Kinase Inhibitors/chemical synthesis; Receptors, Vascular Endothelial Growth Factor/metabolism; Signal Transduction; Structure-Activity Relationship; Sunitinib/analogs & derivatives; Sunitinib/chemical synthesis

Key words

VEGFRs; angiogenesis; anticancer; indolin-2-ones; sunitinib

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Angiogenesis Inhibitors / Receptors, Vascular Endothelial Growth Factor / Protein Kinase Inhibitors / Sunitinib / Indoles / Neoplasms / Neovascularization, Pathologic Limits: Animals / Humans Language: En Journal: Arch Pharm (Weinheim) Year: 2020 Document type: Article Affiliation country: Iran Country of publication: Germany

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