Antibacterial efficacy and discolouration potential of antibiotic pastes with macrogol for regenerative endodontic therapy.

This study aimed to evaluate the antibacterial efficacy and discolouration potential of antibiotic pastes containing macrogol. Seventy single-rooted teeth were contaminated with a culture of Enterococcus faecalis for 30 days. Double (DAP) and triple antibiotic pastes (TAP) containing propylene glycol or macrogol as vehicles were applied. After 15 days, bacterial viability was compared. Change in teeth coronal colour was measured by a spectrophotometer. Statistical analysis was performed using anova and Tukey's test (P < 0.05). TAP containing clindamycin and propylene glycol was the only medicament that led to the presence of contamination, while the same combination of antibiotics containing macrogol did not result in bacterial growth (P < 0.05). Only the pastes containing minocycline in formulation resulted in coronal discolouration (P < 0.05). Both DAPs evaluated and the TAP containing clindamycin and macrogol showed to be the preferable options for regenerative endodontic therapy, as they were effective against E. faecalis biofilm and did not promote tooth discolouration.