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Novel Phenylmethylenecyclohexenone Derivatives as Potent TrxR Inhibitors Display High Antiproliferative Activity and Induce ROS, Apoptosis, and DNA Damage.
Wang, Xiaomei; Qian, Jianqiang; Zhu, Peng; Hua, Rong; Liu, Ji; Hang, Jiaying; Meng, Chi; Shan, Wenpei; Miao, Jiefei; Ling, Yong.
Affiliation
  • Wang X; Department of Pharmacy, The People's Hospital of Taizhou, The Fifth Affiliated Hospital of Nantong University, Taizhou, 225300, China.
  • Qian J; School of Pharmacy and Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong, 226001, China.
  • Zhu P; School of Pharmacy and Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong, 226001, China.
  • Hua R; School of Pharmacy and Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong, 226001, China.
  • Liu J; Department of Pharmacy, The People's Hospital of Taizhou, The Fifth Affiliated Hospital of Nantong University, Taizhou, 225300, China.
  • Hang J; School of Pharmacy and Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong, 226001, China.
  • Meng C; School of Pharmacy and Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong, 226001, China.
  • Shan W; School of Pharmacy and Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong, 226001, China.
  • Miao J; School of Pharmacy and Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong, 226001, China.
  • Ling Y; School of Pharmacy and Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong, 226001, China.
ChemMedChem ; 16(4): 702-712, 2021 02 17.
Article in En | MEDLINE | ID: mdl-33085980
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thioredoxin-Disulfide Reductase / Apoptosis / Cyclohexanones / Enzyme Inhibitors / Antineoplastic Agents Limits: Humans Language: En Journal: ChemMedChem Journal subject: FARMACOLOGIA / QUIMICA Year: 2021 Document type: Article Affiliation country: China Country of publication: Germany
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thioredoxin-Disulfide Reductase / Apoptosis / Cyclohexanones / Enzyme Inhibitors / Antineoplastic Agents Limits: Humans Language: En Journal: ChemMedChem Journal subject: FARMACOLOGIA / QUIMICA Year: 2021 Document type: Article Affiliation country: China Country of publication: Germany