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IgG4-related Sclerosing Cholangitis Complicated with Cholangiocarcinoma and Detected by Forkhead Box P3 Immunohistochemical Staining.
Toyohara, Tadashi; Nakazawa, Takahiro; Zakharia, Kais; Shimizu, Shuya; Miyabe, Katsuyuki; Harada, Kenichi; Notohara, Kenji; Yamada, Tomohiro; Hayashi, Katsumi; Naitoh, Itaru; Hayashi, Kazuki; Kataoka, Hiromi.
Affiliation
  • Toyohara T; Department of Gastroenterology, Japanese Red Cross Nagoya Daini Hospital, Japan.
  • Nakazawa T; Department of Gastroenterology, Japanese Red Cross Nagoya Daini Hospital, Japan.
  • Zakharia K; Division of Gastroenterology and Hepatology, University of Iowa, USA.
  • Shimizu S; Department of Gastroenterology, Japanese Red Cross Nagoya Daini Hospital, Japan.
  • Miyabe K; Department of Gastroenterology, Japanese Red Cross Nagoya Daini Hospital, Japan.
  • Harada K; Department of Human Pathology, Kanazawa University School of Medicine, Japan.
  • Notohara K; Department of Anatomic Pathology, Kurashiki Central Hospital, Japan.
  • Yamada T; Department of Gastroenterology, Japanese Red Cross Nagoya Daini Hospital, Japan.
  • Hayashi K; Department of Gastroenterology, Japanese Red Cross Nagoya Daini Hospital, Japan.
  • Naitoh I; Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan.
  • Hayashi K; Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan.
  • Kataoka H; Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan.
Intern Med ; 60(6): 859-866, 2021 Mar 15.
Article in En | MEDLINE | ID: mdl-33087673
An 80-year-old man was admitted due to biliary stricture with autoimmune pancreatitis. Although radiographical examinations suggested Immunoglobulin G4-related sclerosing cholangitis (IgG4-SC), punched biopsies from the bile duct revealed adenocarcinoma. In the resected specimen, abundant N-terminus of Forkhead box P3 (Foxp3)-positive cells were localized in cholangiocarcinoma (CCA) tissue, while IgG4-positive cells were spread around the entire bile duct. Therefore, the case was diagnosed with IgG4-SC accompanied by CCA, not sporadic CCA. We herein report an informative case wherein IgG4-positive cells were abundant in CCA tissue and Foxp3 immunohistochemical staining allowed us to determine that this case had two entities.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autoimmune Diseases / Bile Duct Neoplasms / Cholangitis, Sclerosing / Cholangiocarcinoma Type of study: Diagnostic_studies Limits: Aged80 / Humans / Male Language: En Journal: Intern Med Journal subject: MEDICINA INTERNA Year: 2021 Document type: Article Affiliation country: Japan Country of publication: Japan

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autoimmune Diseases / Bile Duct Neoplasms / Cholangitis, Sclerosing / Cholangiocarcinoma Type of study: Diagnostic_studies Limits: Aged80 / Humans / Male Language: En Journal: Intern Med Journal subject: MEDICINA INTERNA Year: 2021 Document type: Article Affiliation country: Japan Country of publication: Japan