Dual regulatory effects of PI(4,5)P2 on TREK-2 K+ channel through antagonizing interaction between the alkaline residues (K330 and R355-357) in the cytosolic C-terminal helix.

Kim, Sung Eun; Kim, Myoung-Hwan; Woo, Joohan; Kim, Sung Joon

Dual regulatory effects of PI(4,5)P₂ on TREK-2 K⁺ channel through antagonizing interaction between the alkaline residues (K³³⁰ and R^355-357) in the cytosolic C-terminal helix.

Kim, Sung Eun; Kim, Myoung-Hwan; Woo, Joohan; Kim, Sung Joon.

Affiliation

Kim SE; Department of Physiology, Seoul National University College of Medicine, Gyeongju 38066, Korea.
Kim MH; Department of Physiology, Seoul National University College of Medicine, Gyeongju 38066, Korea.
Woo J; Department of Physiology, Dongguk University College of Medicine, Gyeongju 38066, Korea.
Kim SJ; Channelopathy Research Center (CRC), Dongguk University College of Medicine, Goyang 10326, Korea.

Korean J Physiol Pharmacol ; 24(6): 555-561, 2020 Nov 01.

Article in En | MEDLINE | ID: mdl-33093276

Key words

Amino acids; C-terminal; PIP2; TREK-2; Tandem pore domain potassium channels; basic

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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Korean J Physiol Pharmacol Year: 2020 Document type: Article Country of publication:

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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Korean J Physiol Pharmacol Year: 2020 Document type: Article Country of publication: