PROTACs to address the challenges facing small molecule inhibitors.

Martín-Acosta, Pedro; Xiao, Xiangshu

Martín-Acosta, Pedro; Xiao, Xiangshu.

Affiliation

Martín-Acosta P; Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR, 97239, USA.
Xiao X; Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR, 97239, USA; Knight Cancer Institute, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR, 97239, USA. Electronic address: xiaoxi@ohsu.edu.

Eur J Med Chem ; 210: 112993, 2021 Jan 15.

Article in En | MEDLINE | ID: mdl-33189436

Subject(s)

Proteins/antagonists & inhibitors; Small Molecule Libraries/pharmacology; Humans; Molecular Structure; Proteins/metabolism; Proteolysis/drug effects; Small Molecule Libraries/chemistry

Key words

Cancer; Druggability; Inhibitor; PROTAC; Selectivity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proteins / Small Molecule Libraries Limits: Humans Language: En Journal: Eur J Med Chem Year: 2021 Document type: Article Affiliation country: United States Country of publication: France

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