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Discovery and optimization of a potent and selective indazolamine series of IRAK4 inhibitors.
Zhai, Wenqiang; Lu, Yongping; Zhu, Yabo; Zhou, Mengguang; Ye, Cheng; Shi, Zheng-Zheng; Qian, Wenjian; Hu, Taishan; Chen, Lei.
Affiliation
  • Zhai W; Zhejiang Hisun Pharmaceutical Co. Ltd., China, 46 Waisha Rd., Taizhou 318099, China.
  • Lu Y; Zhejiang Hisun Pharmaceutical Co. Ltd., China, 46 Waisha Rd., Taizhou 318099, China.
  • Zhu Y; Zhejiang Hisun Pharmaceutical Co. Ltd., China, 46 Waisha Rd., Taizhou 318099, China.
  • Zhou M; Zhejiang Hisun Pharmaceutical Co. Ltd., China, 46 Waisha Rd., Taizhou 318099, China.
  • Ye C; Zhejiang Hisun Pharmaceutical Co. Ltd., China, 46 Waisha Rd., Taizhou 318099, China.
  • Shi ZZ; Zhejiang Hisun Pharmaceutical Co. Ltd., China, 46 Waisha Rd., Taizhou 318099, China.
  • Qian W; Zhejiang Hisun Pharmaceutical Co. Ltd., China, 46 Waisha Rd., Taizhou 318099, China. Electronic address: wjqian@hisunpharm.com.
  • Hu T; Zhejiang Hisun Pharmaceutical Co. Ltd., China, 46 Waisha Rd., Taizhou 318099, China.
  • Chen L; Zhejiang Hisun Pharmaceutical Co. Ltd., China, 46 Waisha Rd., Taizhou 318099, China.
Bioorg Med Chem Lett ; 31: 127686, 2021 01 01.
Article in En | MEDLINE | ID: mdl-33242574
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arthritis, Experimental / Anti-Inflammatory Agents, Non-Steroidal / Protein Kinase Inhibitors / Interleukin-1 Receptor-Associated Kinases / Drug Discovery / Amines / Indazoles Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2021 Document type: Article Affiliation country: China Country of publication: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arthritis, Experimental / Anti-Inflammatory Agents, Non-Steroidal / Protein Kinase Inhibitors / Interleukin-1 Receptor-Associated Kinases / Drug Discovery / Amines / Indazoles Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2021 Document type: Article Affiliation country: China Country of publication: United kingdom