Bevacizumab induces oxidative cytotoxicity and apoptosis via TRPM2 channel activation in retinal pigment epithelial cells: Protective role of glutathione.

Özkaya, Dilek; Naziroglu, Mustafa

Özkaya, Dilek; Naziroglu, Mustafa.

Affiliation

Özkaya D; Department of Ophthalmology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey.
Naziroglu M; Neuroscience Research Center, Suleyman Demirel University, Isparta, Turkey. mustafanaziroglu@sdu.edu.tr.

Graefes Arch Clin Exp Ophthalmol ; 259(6): 1539-1554, 2021 Jun.

Article in En | MEDLINE | ID: mdl-33544179

Subject(s)

Glutathione; TRPM Cation Channels; Apoptosis; Bevacizumab/pharmacology; Epithelial Cells/metabolism; Glutathione/metabolism; Humans; Oxidative Stress; Reactive Oxygen Species/metabolism; Retinal Pigments; TRPM Cation Channels/metabolism

Key words

ARPE-19 cells; Apoptosis; Bevacizumab; Oxidative stress; SH-SY5Y cells; TRPM2 channel

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: TRPM Cation Channels / Glutathione Limits: Humans Language: En Journal: Graefes Arch Clin Exp Ophthalmol Year: 2021 Document type: Article Affiliation country: Turkey Country of publication: Germany

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