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Synthesis, biological evaluation and structure-activity relationship of novel dichloroacetophenones targeting pyruvate dehydrogenase kinases with potent anticancer activity.
Xu, Biao; Wang, Zhi-Peng; Liu, Qingwang; Yang, Xiaohong; Li, Xuemin; Huang, Ding; Qiu, Yanfei; Tam, Kin Yip; Zhang, Shao-Lin; He, Yun.
Affiliation
  • Xu B; School of Pharmaceutical Sciences, Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Chongqing University, Chongqing, 401331, PR China.
  • Wang ZP; Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, PR China; Chongqing School, University of Chinese Academy of Sciences Chongqing, PR China.
  • Liu Q; Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, 230031, PR China.
  • Yang X; School of Pharmaceutical Sciences, Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Chongqing University, Chongqing, 401331, PR China.
  • Li X; School of Pharmaceutical Sciences, Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Chongqing University, Chongqing, 401331, PR China.
  • Huang D; School of Pharmaceutical Sciences, Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Chongqing University, Chongqing, 401331, PR China.
  • Qiu Y; School of Pharmaceutical Sciences, Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Chongqing University, Chongqing, 401331, PR China.
  • Tam KY; Faculty of Health Sciences, University of Macau, Taipa, Macau, PR China.
  • Zhang SL; School of Pharmaceutical Sciences, Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Chongqing University, Chongqing, 401331, PR China. Electronic address: zhangsl@cqu.edu.cn.
  • He Y; School of Pharmaceutical Sciences, Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Chongqing University, Chongqing, 401331, PR China. Electronic address: yun.he@cqu.edu.cn.
Eur J Med Chem ; 214: 113225, 2021 Mar 15.
Article in En | MEDLINE | ID: mdl-33550182
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Omega-Chloroacetophenone / Protein Kinase Inhibitors / Pyruvate Dehydrogenase Acetyl-Transferring Kinase / Antineoplastic Agents Limits: Humans Language: En Journal: Eur J Med Chem Year: 2021 Document type: Article Country of publication: France
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Omega-Chloroacetophenone / Protein Kinase Inhibitors / Pyruvate Dehydrogenase Acetyl-Transferring Kinase / Antineoplastic Agents Limits: Humans Language: En Journal: Eur J Med Chem Year: 2021 Document type: Article Country of publication: France