AS602801 sensitizes glioma cells to temozolomide and vincristine by blocking gap junction communication between glioma cells and astrocytes.

Zhang, Shuai; Gong, Yong; Wang, Hongxin; Li, Zhongfan; Huang, Yunfeng; Fu, Xing; Xiang, Peng; Fan, TianYu

Zhang, Shuai; Gong, Yong; Wang, Hongxin; Li, Zhongfan; Huang, Yunfeng; Fu, Xing; Xiang, Peng; Fan, TianYu.

Affiliation

Zhang S; Department of Neurosurgery, ChangSha Central Hospital, Changsha, China.
Gong Y; Department of Neurosurgery, ChangSha Central Hospital, Changsha, China.
Wang H; Department of Neurosurgery, ChangSha Central Hospital, Changsha, China.
Li Z; Department of Neurosurgery, ChangSha Central Hospital, Changsha, China.
Huang Y; Department of Neurosurgery, ChangSha Central Hospital, Changsha, China.
Fu X; Department of Neurosurgery, ChangSha Central Hospital, Changsha, China.
Xiang P; Department of Neurosurgery, ChangSha Central Hospital, Changsha, China.
Fan T; Department of Neurosurgery, ChangSha Central Hospital, Changsha, China.

J Cell Mol Med ; 25(8): 4062-4072, 2021 04.

Article in En | MEDLINE | ID: mdl-33609076

Subject(s)

Antineoplastic Combined Chemotherapy Protocols/pharmacology; Astrocytes/drug effects; Cell Communication; Drug Resistance, Neoplasm/drug effects; Gap Junctions/drug effects; Gene Expression Regulation, Neoplastic/drug effects; Glioma/drug therapy; Animals; Apoptosis; Astrocytes/physiology; Benzothiazoles/administration & dosage; Brain Neoplasms/drug therapy; Brain Neoplasms/metabolism; Brain Neoplasms/pathology; Cell Proliferation; Coculture Techniques; Connexin 43/metabolism; Gap Junctions/physiology; Glioma/metabolism; Glioma/pathology; Humans; Mice; Mice, Inbred NOD; Mice, SCID; Pyrimidines/administration & dosage; Temozolomide/administration & dosage; Tumor Cells, Cultured; Vincristine/administration & dosage; Xenograft Model Antitumor Assays

Key words

AS602801; CX43; JNK; astrocytes; chemotherapeutic; glioma

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antineoplastic Combined Chemotherapy Protocols / Gene Expression Regulation, Neoplastic / Cell Communication / Astrocytes / Gap Junctions / Drug Resistance, Neoplasm / Glioma Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Cell Mol Med Journal subject: BIOLOGIA MOLECULAR Year: 2021 Document type: Article Affiliation country: China Country of publication: United kingdom

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