Hyperosmolarity stimulates transporter-mediated insertion of estrone sulfate into the plasma membrane, but inhibits the uptake by SLC10A1 (NTCP).

Müller, Julian Peter; Keufgens, Lena; Gründemann, Dirk

Müller, Julian Peter; Keufgens, Lena; Gründemann, Dirk.

Affiliation

Müller JP; Department of Pharmacology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Gleueler Straße 24, Cologne 50931, Germany.
Keufgens L; Department of Pharmacology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Gleueler Straße 24, Cologne 50931, Germany.
Gründemann D; Department of Pharmacology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Gleueler Straße 24, Cologne 50931, Germany. Electronic address: dirk.gruendemann@uni-koeln.de.

Biochem Pharmacol ; 186: 114484, 2021 04.

Article in En | MEDLINE | ID: mdl-33617845

Subject(s)

Cell Membrane/metabolism; Estrone/analogs & derivatives; Mannitol/administration & dosage; Organic Anion Transporters, Sodium-Dependent/metabolism; Sucrose/administration & dosage; Symporters/metabolism; Cell Membrane/drug effects; Diuretics, Osmotic/administration & dosage; Dose-Response Relationship, Drug; Estrone/metabolism; Estrone/pharmacology; HEK293 Cells; Humans; Osmolar Concentration; Sweetening Agents/administration & dosage

Key words

Estrone sulfate; Hyperosmolarity; NTCP; Plasma membrane; SLC10A1; SLC22A11; Transporter

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sucrose / Cell Membrane / Organic Anion Transporters, Sodium-Dependent / Symporters / Estrone / Mannitol Limits: Humans Language: En Journal: Biochem Pharmacol Year: 2021 Document type: Article Affiliation country: Germany Country of publication: United kingdom

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