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Loss of mitochondrial aconitase promotes colorectal cancer progression via SCD1-mediated lipid remodeling.
You, Xin; Tian, Jingyu; Zhang, Hui; Guo, Yunhua; Yang, Jing; Zhu, Chaofeng; Song, Ming; Wang, Peng; Liu, Zexian; Cancilla, John; Lu, Wenhua; Glorieux, Christophe; Wen, Shijun; Du, Hongli; Huang, Peng; Hu, Yumin.
Affiliation
  • You X; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, 510060, China; Department of Oncology, Molecular Oncology Research Institute, The First Affiliated Hospital of Fujian Medical University,
  • Tian J; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, 510060, China; Sun Yat-sen University Metabolomics Center, Guangzhou, Guangdong, 510080, China.
  • Zhang H; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, 510060, China; Sun Yat-sen University Metabolomics Center, Guangzhou, Guangdong, 510080, China.
  • Guo Y; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, 510060, China; Sun Yat-sen University Metabolomics Center, Guangzhou, Guangdong, 510080, China.
  • Yang J; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, 510060, China.
  • Zhu C; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, 510060, China.
  • Song M; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, 510060, China.
  • Wang P; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, 510060, China.
  • Liu Z; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, 510060, China.
  • Cancilla J; Scintillon Institute, San Diego, CA 92121, USA.
  • Lu W; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, 510060, China; Sun Yat-sen University Metabolomics Center, Guangzhou, Guangdong, 510080, China.
  • Glorieux C; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, 510060, China.
  • Wen S; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, 510060, China.
  • Du H; School of Biology and Biological Engineering, South China University of Technology, Guangzhou, Guangdong, 510006, China.
  • Huang P; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, 510060, China; Sun Yat-sen University Metabolomics Center, Guangzhou, Guangdong, 510080, China.
  • Hu Y; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, 510060, China; Sun Yat-sen University Metabolomics Center, Guangzhou, Guangdong, 510080, China. Electronic address: huym@sysucc.org.cn.
Mol Metab ; 48: 101203, 2021 06.
Article in En | MEDLINE | ID: mdl-33676027
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stearoyl-CoA Desaturase / Aconitate Hydratase / Colorectal Neoplasms / Signal Transduction / Disease Progression / Lipogenesis / Fatty Acids / Carcinogenesis Limits: Animals / Female / Humans / Male / Middle aged Language: En Journal: Mol Metab Year: 2021 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stearoyl-CoA Desaturase / Aconitate Hydratase / Colorectal Neoplasms / Signal Transduction / Disease Progression / Lipogenesis / Fatty Acids / Carcinogenesis Limits: Animals / Female / Humans / Male / Middle aged Language: En Journal: Mol Metab Year: 2021 Document type: Article