Equivalent potency and pharmacokinetics of recombinant human growth hormones with or without an N-terminal methionine.

Moore, J A; Rudman, C G; MacLachlan, N J; Fuller, G B; Burnett, B; Frane, J W

Moore, J A; Rudman, C G; MacLachlan, N J; Fuller, G B; Burnett, B; Frane, J W.

Affiliation

Moore JA; Department of Pharmacological Sciences, Genentech, Inc. South San Francisco, California 94080.

Endocrinology ; 122(6): 2920-6, 1988 Jun.

Article in En | MEDLINE | ID: mdl-3371267

Subject(s)

Growth Hormone/analogs & derivatives; Growth Hormone/pharmacology; Methionine; Recombinant Proteins/pharmacology; Amino Acid Sequence; Animals; Biological Assay; Body Weight/drug effects; Bone Development/drug effects; Dose-Response Relationship, Drug; Femur; Growth Hormone/pharmacokinetics; Growth Plate/drug effects; Growth Plate/growth & development; Hormones; Human Growth Hormone; Humans; Macaca fascicularis; Male; Recombinant Proteins/pharmacokinetics; Structure-Activity Relationship; Tibia

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Collection: 01-internacional Database: MEDLINE Main subject: Recombinant Proteins / Growth Hormone / Methionine Type of study: Clinical_trials Limits: Animals / Humans / Male Language: En Journal: Endocrinology Year: 1988 Document type: Article

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