Synthesis of Moracin C and Its Derivatives with a 2-arylbenzofuran Motif and Evaluation of Their PCSK9 Inhibitory Effects in HepG2 Cells.

Masagalli, Jagadeesh Nagarajappa; BasavanaGowda, Melanayakanakatte Kuberappa; Chae, Hee-Sung; Choi, Won Jun

Masagalli, Jagadeesh Nagarajappa; BasavanaGowda, Melanayakanakatte Kuberappa; Chae, Hee-Sung; Choi, Won Jun.

Affiliation

Masagalli JN; College of Pharmacy and Integrated Research Institute for Drug Development, Dongguk University, Seoul 04620, Korea.
BasavanaGowda MK; College of Pharmacy and Integrated Research Institute for Drug Development, Dongguk University, Seoul 04620, Korea.
Chae HS; College of Pharmacy and Integrated Research Institute for Drug Development, Dongguk University, Seoul 04620, Korea.
Choi WJ; College of Pharmacy and Integrated Research Institute for Drug Development, Dongguk University, Seoul 04620, Korea.

Molecules ; 26(5)2021 Mar 02.

Article in En | MEDLINE | ID: mdl-33801308

Subject(s)

Benzofurans/chemistry; Enzyme Inhibitors/chemical synthesis; Enzyme Inhibitors/pharmacology; PCSK9 Inhibitors; Stilbenes/chemistry; Cell Proliferation; Hep G2 Cells; Humans

Key words

HepG2 cell lines; cardiovascular diseases; low-density lipoprotein cholesterol; moracin compounds; proprotein convertase subtilisin/kexin type 9; structure activity relationships

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stilbenes / Benzofurans / Enzyme Inhibitors / PCSK9 Inhibitors Type of study: Evaluation_studies / Prognostic_studies Limits: Humans Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2021 Document type: Article Country of publication: Switzerland

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