CRISPR/Cas9-Mediated Genome Editing in Comfrey (<i>Symphytum officinale</i>) Hairy Roots Results in the Complete Eradication of Pyrrolizidine Alkaloids.

Zakaria, Mahmoud M; Schemmerling, Brigitte; Ober, Dietrich

CRISPR/Cas9-Mediated Genome Editing in Comfrey (Symphytum officinale) Hairy Roots Results in the Complete Eradication of Pyrrolizidine Alkaloids.

Zakaria, Mahmoud M; Schemmerling, Brigitte; Ober, Dietrich.

Affiliation

Zakaria MM; Botanisches Institut und Botanischer Garten, Christian-Albrechts-Universität zu Kiel, D-24098 Kiel, Germany.
Schemmerling B; Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University, 44519 Zagazig, Egypt.
Ober D; Botanisches Institut und Botanischer Garten, Christian-Albrechts-Universität zu Kiel, D-24098 Kiel, Germany.

Molecules ; 26(6)2021 Mar 10.

Article in En | MEDLINE | ID: mdl-33801907

Subject(s)

Alkyl and Aryl Transferases/genetics; Comfrey/genetics; Pyrrolizidine Alkaloids/metabolism; Alkyl and Aryl Transferases/metabolism; Boraginaceae/genetics; Boraginaceae/metabolism; CRISPR-Cas Systems/genetics; Comfrey/metabolism; Gene Editing/methods; Gene Expression Regulation, Plant/genetics; Plant Roots/genetics; Plants, Medicinal/genetics; Pyrrolizidine Alkaloids/chemistry

Key words

CRISPR/Cas9; GC-MS; HPLC; alkaloid biosynthesis; genome editing; polyamine analytics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrrolizidine Alkaloids / Alkyl and Aryl Transferases / Comfrey Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2021 Document type: Article Affiliation country: Germany Country of publication: Switzerland

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