A novel approach to residence time distribution characterization in a mAb continuous process.

Brantley, Tim; Bogue, Jon; Denny, Kurtis; Elouafiq, Sanaa; Madren, Seth; Nakhle, Bassam; Khattak, Sarwat

Brantley, Tim; Bogue, Jon; Denny, Kurtis; Elouafiq, Sanaa; Madren, Seth; Nakhle, Bassam; Khattak, Sarwat.

Affiliation

Brantley T; Protein Development, Biogen Inc, Durham, North Carolina, USA.
Bogue J; Analytical Development, Biogen Inc, Durham, North Carolina, USA.
Denny K; Protein Development, Biogen Inc, Durham, North Carolina, USA.
Elouafiq S; Protein Development, Biogen Inc, Durham, North Carolina, USA.
Madren S; Analytical Development, Biogen Inc, Durham, North Carolina, USA.
Nakhle B; Analytical Development, Biogen Inc, Durham, North Carolina, USA.
Khattak S; Protein Development, Biogen Inc, Durham, North Carolina, USA.

Biotechnol Bioeng ; 118(9): 3486-3498, 2021 09.

Article in En | MEDLINE | ID: mdl-33811655

Subject(s)

Antibodies, Monoclonal/biosynthesis; Bioreactors; Animals; CHO Cells; Cricetulus; Glycosylation; Perfusion

Key words

ATF perfusion; Chinese hamster ovary (CHO); product sieving; residence time distribution

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bioreactors / Antibodies, Monoclonal Limits: Animals Language: En Journal: Biotechnol Bioeng Year: 2021 Document type: Article Affiliation country: United States Country of publication: United States

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