Synergizing Off-Target Predictions for In Silico Insights of CENH3 Knockout in Cannabis through CRISPR/Cas.

Hesami, Mohsen; Yoosefzadeh Najafabadi, Mohsen; Adamek, Kristian; Torkamaneh, Davoud; Jones, Andrew Maxwell Phineas

Hesami, Mohsen; Yoosefzadeh Najafabadi, Mohsen; Adamek, Kristian; Torkamaneh, Davoud; Jones, Andrew Maxwell Phineas.

Affiliation

Hesami M; Department of Plant Agriculture, University of Guelph, Guelph, ON N1G 2W1, Canada.
Yoosefzadeh Najafabadi M; Department of Plant Agriculture, University of Guelph, Guelph, ON N1G 2W1, Canada.
Adamek K; Department of Plant Agriculture, University of Guelph, Guelph, ON N1G 2W1, Canada.
Torkamaneh D; Department of Plant Agriculture, University of Guelph, Guelph, ON N1G 2W1, Canada.
Jones AMP; Département de Phytologie, Université Laval, Québec City, QC G1V 0A6, Canada.

Molecules ; 26(7)2021 Apr 03.

Article in En | MEDLINE | ID: mdl-33916717

Subject(s)

CRISPR-Cas Systems/genetics; Cannabis/genetics; Centromere/metabolism; Computer Simulation; Gene Knockout Techniques; Histones/genetics; Area Under Curve; ROC Curve; Support Vector Machine

Key words

CENH3; CFD score; MIT score; ensemble model; genome editing; hemp; machine learning algorithm; marijuana; sgRNA

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Computer Simulation / Cannabis / Histones / Centromere / Gene Knockout Techniques / CRISPR-Cas Systems Type of study: Prognostic_studies / Risk_factors_studies Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2021 Document type: Article Affiliation country: Canada Country of publication: Switzerland

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