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Induced pluripotent stem cell-derived mesenchymal stem cells deliver exogenous miR-105-5p via small extracellular vesicles to rejuvenate senescent nucleus pulposus cells and attenuate intervertebral disc degeneration.
Sun, Yongjin; Zhang, Wenzhi; Li, Xu.
Affiliation
  • Sun Y; Spine Center, Department of Orthopaedics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, No.17, Lujiang Road, Hefei, Anhui, 230001, People's Republic of China.
  • Zhang W; Spine Center, Department of Orthopaedics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, No.17, Lujiang Road, Hefei, Anhui, 230001, People's Republic of China.
  • Li X; Spine Center, Department of Orthopaedics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, No.17, Lujiang Road, Hefei, Anhui, 230001, People's Republic of China. lixu.spine@ustc.edu.cn.
Stem Cell Res Ther ; 12(1): 286, 2021 05 13.
Article in En | MEDLINE | ID: mdl-33985571
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: MicroRNAs / Induced Pluripotent Stem Cells / Intervertebral Disc Degeneration / Mesenchymal Stem Cells / Extracellular Vesicles / Nucleus Pulposus / Intervertebral Disc Type of study: Prognostic_studies Limits: Animals Language: En Journal: Stem Cell Res Ther Year: 2021 Document type: Article Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: MicroRNAs / Induced Pluripotent Stem Cells / Intervertebral Disc Degeneration / Mesenchymal Stem Cells / Extracellular Vesicles / Nucleus Pulposus / Intervertebral Disc Type of study: Prognostic_studies Limits: Animals Language: En Journal: Stem Cell Res Ther Year: 2021 Document type: Article Country of publication: United kingdom