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A PROSS-designed extensively mutated estrogen receptor α variant displays enhanced thermal stability while retaining native allosteric regulation and structure.
Kriegel, Mark; Wiederanders, Hanna J; Alkhashrom, Sewar; Eichler, Jutta; Muller, Yves A.
Affiliation
  • Kriegel M; Division of Biotechnology, Department of Biology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.
  • Wiederanders HJ; Division of Biotechnology, Department of Biology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.
  • Alkhashrom S; Department of Chemistry and Pharmacy, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.
  • Eichler J; Department of Chemistry and Pharmacy, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.
  • Muller YA; Division of Biotechnology, Department of Biology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany. yves.muller@fau.de.
Sci Rep ; 11(1): 10509, 2021 05 18.
Article in En | MEDLINE | ID: mdl-34006920
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Estrogen Receptor alpha Limits: Humans Language: En Journal: Sci Rep Year: 2021 Document type: Article Affiliation country: Germany Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Estrogen Receptor alpha Limits: Humans Language: En Journal: Sci Rep Year: 2021 Document type: Article Affiliation country: Germany Country of publication: United kingdom