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The JAK inhibitor Tofacitinib inhibits structural damage in osteoarthritis by modulating JAK1/TNF-alpha/IL-6 signaling through Mir-149-5p.
Chiu, Yen-Shuo; Bamodu, Oluwaseun Adebayo; Fong, Iat-Hang; Lee, Wei-Hwa; Lin, Chih-Cheng; Lu, Chen-Hsu; Yeh, Chi-Tai.
Affiliation
  • Chiu YS; Department of Orthopedics, Shuang Ho Hospital, Taipei Medical University, Taipei 23561, Taiwan; School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan; Research Center of Geriatric Nutrition, College of Nutrition, Taipei Medical University, Tai
  • Bamodu OA; Department of Medical Research & Education, Taipei Medical University - Shuang Ho Hospital, New Taipei City 235, Taiwan; Department of Urology, Taipei Medical University - Shuang Ho Hospital, New Taipei City 235, Taiwan.
  • Fong IH; Department of Medical Research & Education, Taipei Medical University - Shuang Ho Hospital, New Taipei City 235, Taiwan.
  • Lee WH; Department of Medical Research & Education, Taipei Medical University - Shuang Ho Hospital, New Taipei City 235, Taiwan; Department of Pathology, Taipei Medical University-Shuang Ho Hospital, New Taipei City, Taiwan. Electronic address: whlpath97616@s.tmu.edu.tw.
  • Lin CC; Department of Biotechnology and Pharmaceutical, Yuanpei University of Medical Technology, No. 306, Yuanpei Street, Hsinchu, Taiwan.
  • Lu CH; School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei City 110, Taiwan; Department of Dentistry, Taipei Medical University - Shuang Ho Hospital, New Taipei City 235, Taiwan; Department of Medical Laboratory Science and Biotechnology, Yuanpei University of Medical Technolog
  • Yeh CT; Department of Medical Research & Education, Taipei Medical University - Shuang Ho Hospital, New Taipei City 235, Taiwan; Department of Medical Laboratory Science and Biotechnology, Yuanpei University of Medical Technology, Hsinchu City 30015, Taiwan. Electronic address: ctyeh@s.tmu.edu.tw.
Bone ; 151: 116024, 2021 10.
Article in En | MEDLINE | ID: mdl-34052462
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoarthritis / MicroRNAs / Janus Kinase Inhibitors Type of study: Prognostic_studies Limits: Animals Language: En Journal: Bone Journal subject: METABOLISMO / ORTOPEDIA Year: 2021 Document type: Article Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoarthritis / MicroRNAs / Janus Kinase Inhibitors Type of study: Prognostic_studies Limits: Animals Language: En Journal: Bone Journal subject: METABOLISMO / ORTOPEDIA Year: 2021 Document type: Article Country of publication: United States