How an Infection of Sheep Revealed Prion Mechanisms in Alzheimer's Disease and Other Neurodegenerative Disorders.

Carlson, George A; Prusiner, Stanley B

Carlson, George A; Prusiner, Stanley B.

Affiliation

Carlson GA; Institute for Neurodegenerative Diseases, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA 94158, USA.
Prusiner SB; Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA 94158, USA.

Int J Mol Sci ; 22(9)2021 May 04.

Article in En | MEDLINE | ID: mdl-34064393

Subject(s)

Alzheimer Disease/genetics; Amyloid beta-Peptides/genetics; Prion Proteins/genetics; Scrapie/genetics; alpha-Synuclein/genetics; tau Proteins/genetics; Alzheimer Disease/etiology; Alzheimer Disease/metabolism; Alzheimer Disease/pathology; Amyloid beta-Peptides/chemistry; Amyloid beta-Peptides/metabolism; Animals; Creutzfeldt-Jakob Syndrome/etiology; Creutzfeldt-Jakob Syndrome/genetics; Creutzfeldt-Jakob Syndrome/metabolism; Creutzfeldt-Jakob Syndrome/pathology; Frontotemporal Dementia/etiology; Frontotemporal Dementia/genetics; Frontotemporal Dementia/metabolism; Frontotemporal Dementia/pathology; Gene Expression; Gerstmann-Straussler-Scheinker Disease/etiology; Gerstmann-Straussler-Scheinker Disease/genetics; Gerstmann-Straussler-Scheinker Disease/metabolism; Gerstmann-Straussler-Scheinker Disease/pathology; Humans; Mice; Mutation; Parkinson Disease/etiology; Parkinson Disease/genetics; Parkinson Disease/metabolism; Parkinson Disease/pathology; Prion Proteins/chemistry; Prion Proteins/metabolism; Prions; Protein Folding; Scrapie/etiology; Scrapie/metabolism; Scrapie/pathology; Sheep; alpha-Synuclein/chemistry; alpha-Synuclein/metabolism; tau Proteins/chemistry; tau Proteins/metabolism

Key words

Alzheimer's disease; Aß; PrP; neurodegenerative disease; prions; tau; α-synuclein

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Scrapie / Amyloid beta-Peptides / Tau Proteins / Alpha-Synuclein / Alzheimer Disease / Prion Proteins Type of study: Etiology_studies Language: En Journal: Int J Mol Sci Year: 2021 Document type: Article Affiliation country: United States Country of publication: Switzerland

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