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The common ABCA3E292V variant disrupts AT2 cell quality control and increases susceptibility to lung injury and aberrant remodeling.
Tomer, Yaniv; Wambach, Jennifer; Knudsen, Lars; Zhao, Ming; Rodriguez, Luis R; Murthy, Aditi; White, Frances V; Venosa, Alessandro; Katzen, Jeremy; Ochs, Matthias; Hamvas, Aaron; Beers, Michael F; Mulugeta, Surafel.
Affiliation
  • Tomer Y; Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania.
  • Wambach J; Division of Newborn Medicine, Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri.
  • Knudsen L; Institute of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany.
  • Zhao M; Biomedical Research in End-Stage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany.
  • Rodriguez LR; Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania.
  • Murthy A; Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania.
  • White FV; Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania.
  • Venosa A; Deparment of Pathology & Immunology, Washington University School of Medicine, St. Louis, Missouri.
  • Katzen J; Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah.
  • Ochs M; Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania.
  • Hamvas A; Institute of Functional Anatomy, Charité - Universitaetsmedizin Berlin, Berlin, Germany.
  • Beers MF; German Center for Lung Research, Berlin, Germany.
  • Mulugeta S; Division of Neonatology, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Am J Physiol Lung Cell Mol Physiol ; 321(2): L291-L307, 2021 08 01.
Article in En | MEDLINE | ID: mdl-34132118
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autophagy / Gene Expression Regulation / ATP-Binding Cassette Transporters / Mutation, Missense / Lung Injury / Alveolar Epithelial Cells Type of study: Prognostic_studies Limits: Animals Language: En Journal: Am J Physiol Lung Cell Mol Physiol Journal subject: BIOLOGIA MOLECULAR / FISIOLOGIA Year: 2021 Document type: Article Country of publication: United States
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autophagy / Gene Expression Regulation / ATP-Binding Cassette Transporters / Mutation, Missense / Lung Injury / Alveolar Epithelial Cells Type of study: Prognostic_studies Limits: Animals Language: En Journal: Am J Physiol Lung Cell Mol Physiol Journal subject: BIOLOGIA MOLECULAR / FISIOLOGIA Year: 2021 Document type: Article Country of publication: United States