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Bevacizumab improves tumor infiltration of mature dendritic cells and effector T-cells in triple-negative breast cancer patients.
Boucher, Yves; Kumar, Ashwin S; Posada, Jessica M; Gjini, Evisa; Pfaff, Kathleen; Lipschitz, Mikel; Lako, Ana; Duda, Dan G; Rodig, Scott J; Hodi, F Stephen; Jain, Rakesh K.
Affiliation
  • Boucher Y; Edwin L. Steele Laboratories, Department of Radiation Oncology Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. yves@steele.mgh.harvard.edu.
  • Kumar AS; Edwin L. Steele Laboratories, Department of Radiation Oncology Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Posada JM; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Gjini E; Edwin L. Steele Laboratories, Department of Radiation Oncology Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Pfaff K; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
  • Lipschitz M; Center for Immuno-oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Lako A; Bristol Myers Squibb, Cambridge, MA, USA.
  • Duda DG; Center for Immuno-oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Rodig SJ; Center for Immuno-oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Hodi FS; Center for Immuno-oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Jain RK; Bristol Myers Squibb, Cambridge, MA, USA.
NPJ Precis Oncol ; 5(1): 62, 2021 Jun 29.
Article in En | MEDLINE | ID: mdl-34188163
A single dose of bevacizumab reduced the density of angiopoietin-2-positive vessels while improving the infiltration of CD4+ T and CD8+ T cells, and mature dendritic cells in patients with primary triple-negative breast cancer. Our findings provide a rationale for including bevacizumab during neoadjuvant treatment to enhance the efficacy of immune checkpoint blockers in this disease.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: NPJ Precis Oncol Year: 2021 Document type: Article Affiliation country: United States Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: NPJ Precis Oncol Year: 2021 Document type: Article Affiliation country: United States Country of publication: United kingdom