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Serum urate and cardiovascular events in the DCCT/EDIC study.
Jenkins, Alicia J; Braffett, Barbara H; Basu, Arpita; Bebu, Ionut; Dagogo-Jack, Samuel; Orchard, Trevor J; Wallia, Amisha; Lopes-Virella, Maria F; Garvey, W Timothy; Lachin, John M; Lyons, Timothy J.
Affiliation
  • Jenkins AJ; Division of Endocrinology, Clinical Sciences Building, Suite 822, Medical University of South Carolina, 96 Jonathan Lucas Street, Charleston, SC, 29425, USA.
  • Braffett BH; National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Sydney, Australia.
  • Basu A; George Washington University Biostatistics Center, Rockville, MD, USA.
  • Bebu I; University of Nevada, Las Vegas, NV, USA.
  • Dagogo-Jack S; George Washington University Biostatistics Center, Rockville, MD, USA.
  • Orchard TJ; University of Tennessee Health Science Center, Memphis, TN, USA.
  • Wallia A; University of Pittsburgh, Pittsburgh, PA, USA.
  • Lopes-Virella MF; Northwestern University, Chicago, IL, USA.
  • Garvey WT; Division of Endocrinology, Clinical Sciences Building, Suite 822, Medical University of South Carolina, 96 Jonathan Lucas Street, Charleston, SC, 29425, USA.
  • Lachin JM; Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC, USA.
  • Lyons TJ; University of Alabama at Birmingham, Birmingham VA Medical Center, Birmingham, AL, USA.
Sci Rep ; 11(1): 14182, 2021 07 09.
Article in En | MEDLINE | ID: mdl-34244538
In type 2 diabetes, hyperuricemia is associated with cardiovascular disease (CVD) and the metabolic syndrome (MetS), but associations in type 1 diabetes (T1D) have not been well-defined. This study examined the relationships between serum urate (SU) concentrations, clinical and biochemical factors, and subsequent cardiovascular events in a well-characterized cohort of adults with T1D. In 973 participants with T1D in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study (DCCT/EDIC), associations were defined between SU, measured once in blood collected 1997-2000, and (a) concurrent MetS and (b) incident 'any CVD' and major adverse cardiovascular events (MACE) through 2013. SU was higher in men than women [mean (SD): 4.47 (0.99) vs. 3.39 (0.97) mg/dl, respectively, p < 0.0001], and was associated with MetS features in both (men: p = 0.0016; women: p < 0.0001). During follow-up, 110 participants (11%) experienced "any CVD", and 53 (5%) a MACE. Analyzed by quartiles, SU was not associated with subsequent CVD or MACE. In women, SU as a continuous variable was associated with MACE (unadjusted HR: 1.52; 95% CI 1.07-2.16; p = 0.0211) even after adjustment for age and HbA1c (HR: 1.47; 95% CI 1.01-2.14; p = 0.0467). Predominantly normal range serum urate concentrations in T1D were higher in men than women and were associated with features of the MetS. In some analyses of women only, SU was associated with subsequent MACE. Routine measurement of SU to assess cardiovascular risk in T1D is not merited.Trial registration clinicaltrials.gov NCT00360815 and NCT00360893.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Uric Acid / Cardiovascular Diseases / Diabetes Mellitus, Type 1 Type of study: Etiology_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Sci Rep Year: 2021 Document type: Article Affiliation country: United States Country of publication: United kingdom

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Uric Acid / Cardiovascular Diseases / Diabetes Mellitus, Type 1 Type of study: Etiology_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Sci Rep Year: 2021 Document type: Article Affiliation country: United States Country of publication: United kingdom