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Synthesis and evaluation of novel 2,4-diaminopyrimidines bearing a sulfoxide moiety as anaplastic lymphoma kinase (ALK) inhibition agents.
Wu, Feng; Yao, Han; Li, Wei; Zhang, Niuniu; Fan, Yangyang; Chan, Albert S C; Li, Xingshu; An, Baijiao.
Affiliation
  • Wu F; School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, PR China.
  • Yao H; School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, PR China.
  • Li W; School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, PR China.
  • Zhang N; School of Pharmaceutical Sciences, Guilin Medical University, Guilin 541199, PR China.
  • Fan Y; School of Pharmaceutical Sciences, Binzhou Medical University, Yantai, Shandong Province 264003, PR China.
  • Chan ASC; School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, PR China.
  • Li X; School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, PR China. Electronic address: lixsh@mail.sysu.edu.cn.
  • An B; School of Pharmaceutical Sciences, Binzhou Medical University, Yantai, Shandong Province 264003, PR China. Electronic address: Anbj3@bzmc.edu.cn.
Bioorg Med Chem Lett ; 48: 128253, 2021 09 15.
Article in En | MEDLINE | ID: mdl-34245852
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Safrole / Protein Kinase Inhibitors / Anaplastic Lymphoma Kinase / Antineoplastic Agents Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2021 Document type: Article Country of publication: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Safrole / Protein Kinase Inhibitors / Anaplastic Lymphoma Kinase / Antineoplastic Agents Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2021 Document type: Article Country of publication: United kingdom