Pharmacological inhibition of IRAK1 attenuates colitis-induced tumorigenesis in mice by inhibiting the inflammatory response and epithelial-mesenchymal transition.

Feng, Zeyu; Duan, Zhenglan; Shi, Guoping; Wang, Qiong; Zhou, Jinyong; Chen, Yugen

Feng, Zeyu; Duan, Zhenglan; Shi, Guoping; Wang, Qiong; Zhou, Jinyong; Chen, Yugen.

Affiliation

Feng Z; Department of Colorectal Surgery, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Duan Z; No. 1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Shi G; Department of Colorectal Surgery, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Wang Q; No. 1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Zhou J; No. 1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Chen Y; Central Laboratory, Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu, China.

J Biochem Mol Toxicol ; 35(9): e22838, 2021 Sep.

Article in En | MEDLINE | ID: mdl-34273909

Subject(s)

Carcinogenesis/drug effects; Colitis-Associated Neoplasms/drug therapy; Colitis/drug therapy; Epithelial-Mesenchymal Transition/drug effects; Interleukin-1 Receptor-Associated Kinases/antagonists & inhibitors; Neoplasm Proteins/antagonists & inhibitors; Neoplasms, Experimental/drug therapy; Protein Kinase Inhibitors/pharmacology; Animals; Carcinogenesis/chemically induced; Carcinogenesis/metabolism; Colitis/chemically induced; Colitis/enzymology; Colitis-Associated Neoplasms/chemically induced; Colitis-Associated Neoplasms/enzymology; Inflammation/chemically induced; Inflammation/drug therapy; Inflammation/enzymology; Interleukin-1 Receptor-Associated Kinases/metabolism; Male; Mice; Neoplasm Proteins/metabolism; Neoplasms, Experimental/chemically induced; Neoplasms, Experimental/enzymology

Key words

IL-1 receptor associated kinase; IRAK1/4 inhibitor; azoxymethane/dextran sodium sulfate; colitis-induced tumorigenesis; colorectal cancer; epithelial-mesenchymal transition

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colitis / Protein Kinase Inhibitors / Interleukin-1 Receptor-Associated Kinases / Epithelial-Mesenchymal Transition / Carcinogenesis / Colitis-Associated Neoplasms / Neoplasm Proteins / Neoplasms, Experimental Limits: Animals Language: En Journal: J Biochem Mol Toxicol Journal subject: BIOLOGIA MOLECULAR / BIOQUIMICA / TOXICOLOGIA Year: 2021 Document type: Article Affiliation country: China Country of publication: United States

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