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Local anesthetic bupivacaine inhibits proliferation and metastasis of hepatocellular carcinoma cells via suppressing PI3K/Akt and MAPK signaling.
Wang, Lei; Guo, Weijia; Guan, Hongman; Yan, Ni; Cai, Xiaolan; Zhu, Lili.
Affiliation
  • Wang L; Department of Anesthesiology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
  • Guo W; Department of Anesthesiology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
  • Guan H; Department of Anesthesiology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
  • Yan N; Department of Anesthesiology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
  • Cai X; Department of Anesthesiology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
  • Zhu L; Department of Gynaecology and Obstetrics, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
J Biochem Mol Toxicol ; 35(10): e22871, 2021 Oct.
Article in En | MEDLINE | ID: mdl-34338398
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bupivacaine / Carcinoma, Hepatocellular / Phosphatidylinositol 3-Kinases / MAP Kinase Signaling System / Cell Proliferation / Proto-Oncogene Proteins c-akt / Anesthetics, Local / Liver Neoplasms / Lung Neoplasms Type of study: Observational_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: J Biochem Mol Toxicol Journal subject: BIOLOGIA MOLECULAR / BIOQUIMICA / TOXICOLOGIA Year: 2021 Document type: Article Affiliation country: China Country of publication: United States
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bupivacaine / Carcinoma, Hepatocellular / Phosphatidylinositol 3-Kinases / MAP Kinase Signaling System / Cell Proliferation / Proto-Oncogene Proteins c-akt / Anesthetics, Local / Liver Neoplasms / Lung Neoplasms Type of study: Observational_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: J Biochem Mol Toxicol Journal subject: BIOLOGIA MOLECULAR / BIOQUIMICA / TOXICOLOGIA Year: 2021 Document type: Article Affiliation country: China Country of publication: United States