DNA methylation detection technology and plasma-based methylation biomarkers in screening of gastrointestinal carcinoma.
Epigenomics
; 13(16): 1327-1339, 2021 08.
Article
in En
| MEDLINE
| ID: mdl-34369810
Lay abstract In the context of an increasing global burden of gastrointestinal (GI) carcinoma, early cancer screening is of paramount importance, so there is an urgent need for efficient and reliable potential biomarkers. More biomarkers are emerging with the development of noninvasive test and related detection technologies. This review provides an overview of certain potential biomarkers named DNA methylation, focusing on the presentation and comparison of related detection technologies for this type of biomarkers and introduces the promising plasma-based biomarkers published in recent years for early screening of GI carcinoma. Finally, we summarize and discuss the future of plasma-based biomarkers detection as a clinical tool for early screening of GI carcinoma.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
DNA Methylation
/
Epigenesis, Genetic
/
Epigenomics
/
Circulating Tumor DNA
/
Liquid Biopsy
/
Gastrointestinal Neoplasms
Type of study:
Diagnostic_studies
/
Prognostic_studies
/
Screening_studies
Limits:
Humans
Language:
En
Journal:
Epigenomics
Year:
2021
Document type:
Article
Affiliation country:
China
Country of publication:
United kingdom