Mitochondrial Redox Signaling and Oxidative Stress in Kidney Diseases.
Biomolecules
; 11(8)2021 08 03.
Article
in En
| MEDLINE
| ID: mdl-34439810
Mitochondria are essential organelles in physiology and kidney diseases, because they produce cellular energy required to perform their function. During mitochondrial metabolism, reactive oxygen species (ROS) are produced. ROS function as secondary messengers, inducing redox-sensitive post-translational modifications (PTM) in proteins and activating or deactivating different cell signaling pathways. However, in kidney diseases, ROS overproduction causes oxidative stress (OS), inducing mitochondrial dysfunction and altering its metabolism and dynamics. The latter processes are closely related to changes in the cell redox-sensitive signaling pathways, causing inflammation and apoptosis cell death. Although mitochondrial metabolism, ROS production, and OS have been studied in kidney diseases, the role of redox signaling pathways in mitochondria has not been addressed. This review focuses on altering the metabolism and dynamics of mitochondria through the dysregulation of redox-sensitive signaling pathways in kidney diseases.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Protein Processing, Post-Translational
/
Reactive Oxygen Species
/
Oxidative Stress
/
Renal Insufficiency, Chronic
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Acute Kidney Injury
/
Mitochondria
Limits:
Humans
Language:
En
Journal:
Biomolecules
Year:
2021
Document type:
Article
Affiliation country:
Mexico
Country of publication:
Switzerland