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Lifestyle and the aging brain: interactive effects of modifiable lifestyle behaviors and cognitive ability in men from midlife to old age.
Franz, Carol E; Hatton, Sean N; Elman, Jeremy A; Warren, Teresa; Gillespie, Nathan A; Whitsel, Nathan A; Puckett, Olivia K; Dale, Anders M; Eyler, Lisa T; Fennema-Notestine, Christine; Hagler, Donald J; Hauger, Richard L; McKenzie, Ruth; Neale, Michael C; Panizzon, Matthew S; Pearce, Rahul C; Reynolds, Chandra A; Sanderson-Cimino, Mark; Toomey, Rosemary; Tu, Xin M; Williams, McKenna; Xian, Hong; Lyons, Michael J; Kremen, William S.
Affiliation
  • Franz CE; Department of Psychiatry, University of California San Diego, San Diego, CA, USA; Center for Behavior Genetics of Aging, University of California San Diego, San Diego, CA, USA. Electronic address: cfranz@health.ucsd.edu.
  • Hatton SN; Department of Radiology, University of California San Diego, San Diego, CA, USA.
  • Elman JA; Department of Psychiatry, University of California San Diego, San Diego, CA, USA; Center for Behavior Genetics of Aging, University of California San Diego, San Diego, CA, USA.
  • Warren T; Department of Psychology, San Diego State University, San Diego, CA, USA.
  • Gillespie NA; Virginia Institute for Psychiatric and Behavior Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA; QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
  • Whitsel NA; Department of Psychiatry, University of California San Diego, San Diego, CA, USA; Center for Behavior Genetics of Aging, University of California San Diego, San Diego, CA, USA.
  • Puckett OK; Department of Psychiatry, University of California San Diego, San Diego, CA, USA; Center for Behavior Genetics of Aging, University of California San Diego, San Diego, CA, USA.
  • Dale AM; Department of Radiology, University of California San Diego, San Diego, CA, USA.
  • Eyler LT; Department of Psychiatry, University of California San Diego, San Diego, CA, USA; Center for Behavior Genetics of Aging, University of California San Diego, San Diego, CA, USA.
  • Fennema-Notestine C; Department of Psychiatry, University of California San Diego, San Diego, CA, USA; Center for Behavior Genetics of Aging, University of California San Diego, San Diego, CA, USA; Department of Radiology, University of California San Diego, San Diego, CA, USA.
  • Hagler DJ; Department of Radiology, University of California San Diego, San Diego, CA, USA.
  • Hauger RL; Department of Psychiatry, University of California San Diego, San Diego, CA, USA; Center for Behavior Genetics of Aging, University of California San Diego, San Diego, CA, USA; Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego, CA, USA.
  • McKenzie R; Department of Psychological and Brain Sciences, Boston University, Boston, MA, USA.
  • Neale MC; Virginia Institute for Psychiatric and Behavior Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
  • Panizzon MS; Department of Psychiatry, University of California San Diego, San Diego, CA, USA; Center for Behavior Genetics of Aging, University of California San Diego, San Diego, CA, USA.
  • Pearce RC; Department of Psychiatry, University of California San Diego, San Diego, CA, USA; Center for Behavior Genetics of Aging, University of California San Diego, San Diego, CA, USA.
  • Reynolds CA; Department of Psychology, University of California Riverside, Riverside, CA, USA.
  • Sanderson-Cimino M; San Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA; Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego, CA, USA.
  • Toomey R; Department of Psychological and Brain Sciences, Boston University, Boston, MA, USA.
  • Tu XM; Department of Family Medicine, University of California San Diego, San Diego, CA, USA.
  • Williams M; Department of Psychiatry, University of California San Diego, San Diego, CA, USA; Center for Behavior Genetics of Aging, University of California San Diego, San Diego, CA, USA; San Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA,
  • Xian H; Department of Epidemiology & Biostatistics, St. Louis University, St. Louis, MO, USA.
  • Lyons MJ; Department of Psychological and Brain Sciences, Boston University, Boston, MA, USA.
  • Kremen WS; Department of Psychiatry, University of California San Diego, San Diego, CA, USA; Center for Behavior Genetics of Aging, University of California San Diego, San Diego, CA, USA.
Neurobiol Aging ; 108: 80-89, 2021 12.
Article in En | MEDLINE | ID: mdl-34547718
We examined the influence of lifestyle on brain aging after nearly 30 years, and tested the hypothesis that young adult general cognitive ability (GCA) would moderate these effects. In the community-dwelling Vietnam Era Twin Study of Aging (VETSA), 431 largely non-Hispanic white men completed a test of GCA at mean age 20. We created a modifiable lifestyle behavior composite from data collected at mean age 40. During VETSA, MRI-based measures at mean age 68 included predicted brain age difference (PBAD), Alzheimer's disease (AD) brain signature, and abnormal white matter scores. There were significant main effects of young adult GCA and lifestyle on PBAD and the AD signature (ps ≤ 0.012), and a GCA-by-lifestyle interaction on both (ps ≤ 0.006). Regardless of GCA level, having more favorable lifestyle behaviors predicted less advanced brain age and less AD-like brain aging. Unfavorable lifestyles predicted advanced brain aging in those with lower age 20 GCA, but did not affect brain aging in those with higher age 20 GCA. Targeting early lifestyle modification may promote dementia risk reduction, especially among lower reserve individuals.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Behavior / Aging / Cognition / Independent Living / Cognitive Reserve / Alzheimer Disease / Healthy Lifestyle / Life Style Type of study: Prognostic_studies Limits: Adult / Aged / Humans / Male / Middle aged Language: En Journal: Neurobiol Aging Year: 2021 Document type: Article Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Behavior / Aging / Cognition / Independent Living / Cognitive Reserve / Alzheimer Disease / Healthy Lifestyle / Life Style Type of study: Prognostic_studies Limits: Adult / Aged / Humans / Male / Middle aged Language: En Journal: Neurobiol Aging Year: 2021 Document type: Article Country of publication: United States