Effect of Sox9 on TGF-ß1-mediated atrial fibrosis.

Wang, Hechuan; Chen, Yiqi; Zhao, Shuting; Wang, Xiaowen; Lu, Kai; Xiao, Hua

Wang, Hechuan; Chen, Yiqi; Zhao, Shuting; Wang, Xiaowen; Lu, Kai; Xiao, Hua.

Affiliation

Wang H; Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Chen Y; Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Zhao S; Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Wang X; Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Lu K; Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Xiao H; Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

Acta Biochim Biophys Sin (Shanghai) ; 53(11): 1450-1458, 2021 Nov 10.

Article in En | MEDLINE | ID: mdl-34596216

Subject(s)

Atrial Fibrillation/genetics; Fibroblasts/metabolism; Heart Defects, Congenital/genetics; Rheumatic Heart Disease/genetics; SOX9 Transcription Factor/genetics; Transforming Growth Factor beta1/genetics; Actins/genetics; Actins/metabolism; Adult; Animals; Atrial Fibrillation/metabolism; Atrial Fibrillation/pathology; Atrial Fibrillation/surgery; Cell Movement; Collagen Type I/genetics; Collagen Type I/metabolism; Connexin 43/genetics; Connexin 43/metabolism; Female; Fibroblasts/pathology; Fibrosis; Gene Expression Regulation; Heart Atria/metabolism; Heart Atria/pathology; Heart Atria/surgery; Heart Defects, Congenital/metabolism; Heart Defects, Congenital/pathology; Heart Defects, Congenital/surgery; Humans; Male; Middle Aged; Primary Cell Culture; RNA, Messenger/genetics; RNA, Messenger/metabolism; Rats; Rats, Sprague-Dawley; Rheumatic Heart Disease/metabolism; Rheumatic Heart Disease/pathology; Rheumatic Heart Disease/surgery; SOX9 Transcription Factor/metabolism; Signal Transduction; Transforming Growth Factor beta1/metabolism

Key words

Sox9; TGF-ß1; atrial fibrillation; atrial fibrosis; atrial remodeling

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Rheumatic Heart Disease / Atrial Fibrillation / Transforming Growth Factor beta1 / SOX9 Transcription Factor / Fibroblasts / Heart Defects, Congenital Language: En Journal: Acta Biochim Biophys Sin (Shanghai) Journal subject: BIOFISICA / BIOQUIMICA Year: 2021 Document type: Article Affiliation country: China Country of publication: China

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