Changes in MDA5 and TLR3 Sensing of the Same Diabetogenic Virus Result in Different Autoimmune Disease Outcomes.

Lincez, Pamela J; Shanina, Iryna; Horwitz, Marc S

Lincez, Pamela J; Shanina, Iryna; Horwitz, Marc S.

Affiliation

Lincez PJ; Michael Smith Laboratories, The University of British Columbia, Vancouver, BC, Canada.
Shanina I; Department of Microbiology & Immunology, Life Sciences Institute, The University of British Columbia, Vancouver, BC, Canada.
Horwitz MS; Department of Microbiology & Immunology, Life Sciences Institute, The University of British Columbia, Vancouver, BC, Canada.

Front Immunol ; 12: 751341, 2021.

Article in En | MEDLINE | ID: mdl-34804036

Subject(s)

Coxsackievirus Infections/immunology; Cytokines/immunology; Diabetes Mellitus, Type 1/immunology; Interferon-Induced Helicase, IFIH1/immunology; Toll-Like Receptor 3/immunology; Animals; Enterovirus B, Human; Female; Interferon-Induced Helicase, IFIH1/genetics; Male; Mice, Inbred NOD; Mice, Transgenic; Toll-Like Receptor 3/genetics

Key words

MDA5; TLR3; autoimmunity; coxsackievirus; diabetes; interferon; interferonopathy

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cytokines / Coxsackievirus Infections / Diabetes Mellitus, Type 1 / Toll-Like Receptor 3 / Interferon-Induced Helicase, IFIH1 Limits: Animals Language: En Journal: Front Immunol Year: 2021 Document type: Article Affiliation country: Canada Country of publication: Switzerland

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