Genetic correction of TRMU allele restored the mitochondrial dysfunction-induced deficiencies in iPSCs-derived hair cells of hearing-impaired patients.

Chen, Chao; Guan, Min-Xin

Chen, Chao; Guan, Min-Xin.

Affiliation

Chen C; Division of Medical Genetics and Genomics, The Children's Hospital, Zhejiang University School of Medicine and National Clinical Research Center for Child Health, Hangzhou, Zhejiang 310058, China.
Guan MX; Institute of Genetics, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China.

Hum Mol Genet ; 31(18): 3068-3082, 2022 09 10.

Article in En | MEDLINE | ID: mdl-35467742

Subject(s)

Hearing Loss; Induced Pluripotent Stem Cells; Alleles; DNA, Mitochondrial/genetics; Hair/metabolism; Hearing; Hearing Loss/genetics; Hearing Loss/metabolism; Humans; Induced Pluripotent Stem Cells/metabolism; Mechanotransduction, Cellular; Mitochondria/genetics; Mitochondria/metabolism; Mitochondrial Proteins/genetics; Mutation; RNA, Ribosomal/genetics; RNA, Transfer/metabolism; tRNA Methyltransferases/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Induced Pluripotent Stem Cells / Hearing Loss Limits: Humans Language: En Journal: Hum Mol Genet Journal subject: BIOLOGIA MOLECULAR / GENETICA MEDICA Year: 2022 Document type: Article Affiliation country: China Country of publication: United kingdom

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