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INZ-701, a recombinant ENPP1 enzyme, prevents ectopic calcification in an Abcc6-/- mouse model of pseudoxanthoma elasticum.
Jacobs, Ida Joely; Cheng, Zhiliang; Ralph, Douglas; O'Brien, Kevin; Flaman, Lisa; Howe, Jennifer; Thompson, David; Uitto, Jouni; Li, Qiaoli; Sabbagh, Yves.
Affiliation
  • Jacobs IJ; Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College, Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
  • Cheng Z; PXE International Center of Excellence in Research and Clinical Care, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
  • Ralph D; Inozyme Pharma, Boston, Massachusetts, USA.
  • O'Brien K; Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College, Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
  • Flaman L; PXE International Center of Excellence in Research and Clinical Care, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
  • Howe J; Genetics, Genomics and Cancer Biology PhD Program, Jefferson College of Life Sciences, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
  • Thompson D; Inozyme Pharma, Boston, Massachusetts, USA.
  • Uitto J; Inozyme Pharma, Boston, Massachusetts, USA.
  • Li Q; Inozyme Pharma, Boston, Massachusetts, USA.
  • Sabbagh Y; Inozyme Pharma, Boston, Massachusetts, USA.
Exp Dermatol ; 31(7): 1095-1101, 2022 07.
Article in En | MEDLINE | ID: mdl-35511611
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pseudoxanthoma Elasticum / Pyrophosphatases / Calcinosis / Phosphoric Diester Hydrolases Limits: Animals / Humans Language: En Journal: Exp Dermatol Journal subject: DERMATOLOGIA Year: 2022 Document type: Article Affiliation country: United States Country of publication: Denmark
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pseudoxanthoma Elasticum / Pyrophosphatases / Calcinosis / Phosphoric Diester Hydrolases Limits: Animals / Humans Language: En Journal: Exp Dermatol Journal subject: DERMATOLOGIA Year: 2022 Document type: Article Affiliation country: United States Country of publication: Denmark