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Changes in phrenic nerve compound muscle action potential in streptozotocin-induced diabetic rats.
Ferrari, Marcelo C; Peixoto, João V; Fogaça, Rosalvo H; Dias, Fernando A.
Affiliation
  • Ferrari MC; Laboratory of Cardiovascular Physiology and Pathophysiology, Department of Physiology, Federal University of Paraná, Brazil.
  • Peixoto JV; Laboratory of Cardiovascular Physiology and Pathophysiology, Department of Physiology, Federal University of Paraná, Brazil.
  • Fogaça RH; Laboratory of Cardiovascular Physiology and Pathophysiology, Department of Physiology, Federal University of Paraná, Brazil.
  • Dias FA; Laboratory of Cardiovascular Physiology and Pathophysiology, Department of Physiology, Federal University of Paraná, Brazil. Electronic address: faldias@ufpr.br.
Respir Physiol Neurobiol ; 303: 103923, 2022 09.
Article in En | MEDLINE | ID: mdl-35654367
PURPOSE: To evaluate the phrenic nerve compound muscle action potential (CMAP) in rats after diabetes mellitus (DM) induction. METHODS: Twenty DM animals (intravenous streptozotocin, 45 mg.kg-1) and 25 controls underwent CMAP analysis before and 30, 60 and 90 days after DM induction. RESULTS: Amplitude (mV) progressively declined in DM group after 30 (Mean difference (MD): -0.915, 95 % Confidence interval (CI) -1.580 to -0.250, p < 0.01), 60 (MD: -1.122, 95 % CI -1.664 to -0.581, p < 0.001) and 90 days (MD: -2.226, 95 % CI -3.059 to -1.393, p < 0.001); as well as the area (mV.ms) after 30 (MD: -3.19, 95 % CI -5.94 to -0.44, p < 0.05), 60 (MD: -3.94, 95 % CI -6.24 to -1.64, p < 0.001) and 90 days (MD: -8.64, 95 % CI -12.08 to -5.21, p < 0.001). Transient differences were observed in latency and duration at 60 days. CONCLUSIONS: The progressive changes in phrenic nerve CMAP observed during DM suggest a decrement in axonal function rather than substantial demyelination.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phrenic Nerve / Diabetes Mellitus, Experimental Limits: Animals Language: En Journal: Respir Physiol Neurobiol Year: 2022 Document type: Article Affiliation country: Brazil Country of publication: Netherlands

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phrenic Nerve / Diabetes Mellitus, Experimental Limits: Animals Language: En Journal: Respir Physiol Neurobiol Year: 2022 Document type: Article Affiliation country: Brazil Country of publication: Netherlands