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Ursolic acid inhibits the cholesterol biosynthesis and alleviates high fat diet-induced hypercholesterolemia via irreversible inhibition of HMGCS1 in vivo.
Ma, Xiaoyao; Bai, Yongping; Liu, Kaixin; Han, Yiman; Zhang, Jinling; Liu, Yuteng; Hou, Xiaotao; Hao, Erwei; Hou, Yuanyuan; Bai, Gang.
Affiliation
  • Ma X; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China.
  • Bai Y; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China.
  • Liu K; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China.
  • Han Y; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China.
  • Zhang J; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China.
  • Liu Y; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China.
  • Hou X; Guangxi Collaborative Innovation Center for Functional Ingredients Study of Agricultural Residues, Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica, Guangxi University of Chinese Medicine, Nanning, China.
  • Hao E; Guangxi Collaborative Innovation Center for Functional Ingredients Study of Agricultural Residues, Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica, Guangxi University of Chinese Medicine, Nanning, China.
  • Hou Y; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China.
  • Bai G; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China. Electronic address: gangbai@nankai.edu.cn.
Phytomedicine ; 103: 154233, 2022 Aug.
Article in En | MEDLINE | ID: mdl-35671633
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Atherosclerosis / Hypercholesterolemia Limits: Animals Language: En Journal: Phytomedicine Journal subject: TERAPIAS COMPLEMENTARES Year: 2022 Document type: Article Affiliation country: China Country of publication: Germany
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Atherosclerosis / Hypercholesterolemia Limits: Animals Language: En Journal: Phytomedicine Journal subject: TERAPIAS COMPLEMENTARES Year: 2022 Document type: Article Affiliation country: China Country of publication: Germany