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A Barrier to Defend - Models of Pulmonary Barrier to Study Acute Inflammatory Diseases.
Herminghaus, Anna; Kozlov, Andrey V; Szabó, Andrea; Hantos, Zoltán; Gylstorff, Severin; Kuebart, Anne; Aghapour, Mahyar; Wissuwa, Bianka; Walles, Thorsten; Walles, Heike; Coldewey, Sina M; Relja, Borna.
Affiliation
  • Herminghaus A; Department of Anaesthesiology, University of Duesseldorf, Duesseldorf, Germany.
  • Kozlov AV; L Boltzmann Institute for Traumatology in Cooperation with AUVA and Austrian Cluster for Tissue Regeneration, Vienna, Austria.
  • Szabó A; Department of Human Pathology , IM Sechenov Moscow State Medical University, Moscow, Russia.
  • Hantos Z; Institute of Surgical Research, University of Szeged, Szeged, Hungary.
  • Gylstorff S; Department of Anaesthesiology and Intensive Therapy, Semmelweis University, Budapest, Hungary.
  • Kuebart A; Experimental Radiology, Department of Radiology and Nuclear Medicine, Otto-von-Guericke University, Magdeburg, Germany.
  • Aghapour M; Research Campus STIMULATE, Otto-von-Guericke University, Magdeburg, Germany.
  • Wissuwa B; Department of Anaesthesiology, University of Duesseldorf, Duesseldorf, Germany.
  • Walles T; Experimental Radiology, Department of Radiology and Nuclear Medicine, Otto-von-Guericke University, Magdeburg, Germany.
  • Walles H; Department of Anaesthesiology and Intensive Care Medicine, Septomics Research Centre, Centre for Sepsis Control and Care, Jena University Hospital, Jena, Germany.
  • Coldewey SM; Department of Thoracic Surgery, Magdeburg University Medicine, Magdeburg, Germany.
  • Relja B; Research Campus STIMULATE, Otto-von-Guericke University, Magdeburg, Germany.
Front Immunol ; 13: 895100, 2022.
Article in En | MEDLINE | ID: mdl-35874776
Pulmonary diseases represent four out of ten most common causes for worldwide mortality. Thus, pulmonary infections with subsequent inflammatory responses represent a major public health concern. The pulmonary barrier is a vulnerable entry site for several stress factors, including pathogens such as viruses, and bacteria, but also environmental factors e.g. toxins, air pollutants, as well as allergens. These pathogens or pathogen-associated molecular pattern and inflammatory agents e.g. damage-associated molecular pattern cause significant disturbances in the pulmonary barrier. The physiological and biological functions, as well as the architecture and homeostatic maintenance of the pulmonary barrier are highly complex. The airway epithelium, denoting the first pulmonary barrier, encompasses cells releasing a plethora of chemokines and cytokines, and is further covered with a mucus layer containing antimicrobial peptides, which are responsible for the pathogen clearance. Submucosal antigen-presenting cells and neutrophilic granulocytes are also involved in the defense mechanisms and counterregulation of pulmonary infections, and thus may directly affect the pulmonary barrier function. The detailed understanding of the pulmonary barrier including its architecture and functions is crucial for the diagnosis, prognosis, and therapeutic treatment strategies of pulmonary diseases. Thus, considering multiple side effects and limited efficacy of current therapeutic treatment strategies in patients with inflammatory diseases make experimental in vitro and in vivo models necessary to improving clinical therapy options. This review describes existing models for studyying the pulmonary barrier function under acute inflammatory conditions, which are meant to improve the translational approaches for outcome predictions, patient monitoring, and treatment decision-making.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pneumonia / Lung Type of study: Prognostic_studies / Systematic_reviews Limits: Humans Language: En Journal: Front Immunol Year: 2022 Document type: Article Affiliation country: Germany Country of publication: Switzerland

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pneumonia / Lung Type of study: Prognostic_studies / Systematic_reviews Limits: Humans Language: En Journal: Front Immunol Year: 2022 Document type: Article Affiliation country: Germany Country of publication: Switzerland