Identification of LARS as an essential gene for osteosarcoma proliferation through large-Scale CRISPR-Cas9 screening database and experimental verification.

Chen, Wenhao; Lin, Yuxiang; Jiang, Meichen; Wang, Qingshui; Shu, Qiang

Chen, Wenhao; Lin, Yuxiang; Jiang, Meichen; Wang, Qingshui; Shu, Qiang.

Affiliation

Chen W; Department of Orthopedics, The Children's Hospital, Zhejiang University School of Medicine, National Children's Regional Medical Center, National Clinical Research Center for Child Health, 3333 Bingsheng Road, Hangzhou, 310052, Zhejiang Province, China.
Lin Y; Department of Breast Surgery, Fujian Medical University Union Hospital, 29 Xinquan Road, Fuzhou, 350001, Fujian Province, China.
Jiang M; Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou, 350001, Fujian Province, China.
Wang Q; Breast Cancer Institute, Fujian Medical University, Fuzhou, Fujian Province, China.
Shu Q; Department of Pathology, Fujian Medical University Union Hospital, 29 Xinquan Road, Fuzhou, 350001, Fujian Province, China.

J Transl Med ; 20(1): 355, 2022 08 12.

Article in En | MEDLINE | ID: mdl-35962451

Subject(s)

Bone Neoplasms; Leucine-tRNA Ligase/genetics; Osteosarcoma; Adolescent; Bone Neoplasms/genetics; CRISPR-Cas Systems/genetics; Cell Line, Tumor; Cell Proliferation/genetics; Child; Genes, Essential; Humans; Osteosarcoma/genetics; Osteosarcoma/pathology

Key words

CRISPR-Cas9; Depmap; LARS; Osteosarcoma; Proliferation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bone Neoplasms / Osteosarcoma / Leucine-tRNA Ligase Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Limits: Adolescent / Child / Humans Language: En Journal: J Transl Med Year: 2022 Document type: Article Affiliation country: China Country of publication: United kingdom

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