PIK3R2 predicts poor outcomes for patients with melanoma and contributes to the malignant progression via PI3K/AKT/NF-&#954;B axis.

Wang, Jianguo; Cai, Shizhong; Xiong, Qianwei; Weng, Deyu; Wang, Qian; Ma, Zhourui

PIK3R2 predicts poor outcomes for patients with melanoma and contributes to the malignant progression via PI3K/AKT/NF-κB axis.

Wang, Jianguo; Cai, Shizhong; Xiong, Qianwei; Weng, Deyu; Wang, Qian; Ma, Zhourui.

Affiliation

Wang J; Department of Surgery, Nanjing Pukou Central Hospital (Pukou Branch Hospital of Jiangsu Province Hospital), Nanjing, 211800, Jiangsu, People's Republic of China.
Cai S; Department of Child and Adolescent Healthcare, Children's Hospital of Soochow University, Suzhou, 215025, Jiangsu, People's Republic of China.
Xiong Q; Suzhou Key Laboratory of Structural Deformities in Children, No. 92 Zhongnan Street, Suzhou, 215025, Jiangsu, People's Republic of China.
Weng D; Department of Urology, Children's Hospital of Soochow University, Suzhou, 215025, Jiangsu, People's Republic of China.
Wang Q; Suzhou Key Laboratory of Structural Deformities in Children, No. 92 Zhongnan Street, Suzhou, 215025, Jiangsu, People's Republic of China.
Ma Z; Department of Surgery, Nanjing Pukou Central Hospital (Pukou Branch Hospital of Jiangsu Province Hospital), Nanjing, 211800, Jiangsu, People's Republic of China.

Clin Transl Oncol ; 25(5): 1402-1412, 2023 May.

Article in En | MEDLINE | ID: mdl-36528701

Subject(s)

Melanoma; Phosphatidylinositol 3-Kinases; Skin Neoplasms; Humans; Cell Line, Tumor; Cell Movement; Cell Proliferation; Melanoma/genetics; Melanoma/metabolism; Melanoma/pathology; MicroRNAs/metabolism; NF-kappa B/metabolism; Phosphatidylinositol 3-Kinases/genetics; Phosphatidylinositol 3-Kinases/metabolism; Proto-Oncogene Proteins c-akt/metabolism; Signal Transduction; Skin Neoplasms/genetics; Skin Neoplasms/metabolism

Key words

Apoptosis; Invasion; Melanoma; PI3K/AKT/NF-κB; PIK3R2; Proliferation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Skin Neoplasms / Phosphatidylinositol 3-Kinases / Melanoma Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Clin Transl Oncol Year: 2023 Document type: Article Country of publication: Italy

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