Development and optimization of stability-indicating method of ethinylestradiol, levonorgestrel, and their main impurities using quality by design approach.

da Silva, Fernando Antunes; Lourenço, Felipe Rebello; Calixto, Leandro Augusto

da Silva, Fernando Antunes; Lourenço, Felipe Rebello; Calixto, Leandro Augusto.

Affiliation

da Silva FA; Federal University of São Paulo, Diadema 09913-030, Brazil.
Lourenço FR; University of São Paulo, São Paulo 05508-000, Brazil.
Calixto LA; Federal University of São Paulo, Diadema 09913-030, Brazil. Electronic address: lcalixto@unifesp.br.

J Pharm Biomed Anal ; 225: 115208, 2023 Feb 20.

Article in En | MEDLINE | ID: mdl-36586384

Subject(s)

Ethinyl Estradiol; Levonorgestrel; Humans; Chromatography, High Pressure Liquid/methods; Drug Stability; Contraceptive Agents; Reproducibility of Results

Key words

Design of experiments; Liquid chromatography; Molecular descriptors; Monte Carlo method; Quantitative structure-retention relationships

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Levonorgestrel / Ethinyl Estradiol Limits: Humans Language: En Journal: J Pharm Biomed Anal Year: 2023 Document type: Article Affiliation country: Brazil Country of publication: United kingdom

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