Utility of propensity score-based Bayesian borrowing of external adult data in pediatric trials: A pragmatic evaluation through a case study in acute lymphoblastic leukemia (ALL).

Majumdar, Antara; Rothwell, Rebecca; Reaman, Gregory; Ahlberg, Corinne; Roy, Pourab

Majumdar, Antara; Rothwell, Rebecca; Reaman, Gregory; Ahlberg, Corinne; Roy, Pourab.

Affiliation

Majumdar A; Oncology Biostatistics, GlaxoSmithKline, Collegeville, PA, USA.
Rothwell R; Office of Biostatistics, U.S. Food and Drug Administration, Silver Spring, MD, USA.
Reaman G; Oncology Center of Excellence, U.S. Food and Drug Administration, Silver Spring, MD, USA.
Ahlberg C; Acorn AI by Medidata, a Dassault Systèmes company, New York, NY, USA.
Roy P; Biostatistics, Regeneron Pharmaceuticals, Tarrytown, NY, USA.

J Biopharm Stat ; 33(6): 737-751, 2023 11 02.

Article in En | MEDLINE | ID: mdl-36600441

Subject(s)

Precursor Cell Lymphoblastic Leukemia-Lymphoma; Research Design; Humans; Adult; Child; Bayes Theorem; Propensity Score; Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy; Precursor Cell Lymphoblastic Leukemia-Lymphoma/epidemiology; Computer Simulation

Key words

Bayesian borrowing; external controls; mixture prior; pediatric trials; power prior; propensity scores

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Research Design / Precursor Cell Lymphoblastic Leukemia-Lymphoma Type of study: Clinical_trials / Prognostic_studies Limits: Adult / Child / Humans Language: En Journal: J Biopharm Stat Journal subject: FARMACOLOGIA Year: 2023 Document type: Article Affiliation country: United States Country of publication: United kingdom

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