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Combining high throughput array synthesis and growth algorithm to discover TNF-α binders with new structures and properties.
Lin, Weilin; Gandhi, Shanil; Bhattarai, Prabesh; Kasa, Keida; Kizil, Caghan; Zhang, Yixin.
Affiliation
  • Lin W; B CUBE Center for Molecular Bioengineering, Technische Universität Dresden, Tatzberg 41, 01307, Dresden, Germany; Suzhou Institute of Systems Medicine, Suzhou, Jiangsu, China.
  • Gandhi S; B CUBE Center for Molecular Bioengineering, Technische Universität Dresden, Tatzberg 41, 01307, Dresden, Germany.
  • Bhattarai P; Department of Neurology and The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, 650 W 168th St, New York, NY, 10032, USA.
  • Kasa K; B CUBE Center for Molecular Bioengineering, Technische Universität Dresden, Tatzberg 41, 01307, Dresden, Germany.
  • Kizil C; Department of Neurology and The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, 650 W 168th St, New York, NY, 10032, USA. Electronic address: ck2893@cumc.columbia.edu.
  • Zhang Y; B CUBE Center for Molecular Bioengineering, Technische Universität Dresden, Tatzberg 41, 01307, Dresden, Germany; Cluster of Excellence "Physics of Life", Technische Universität Dresden, 01062, Dresden, Germany. Electronic address: yixin.zhang1@tu-dresden.de.
Eur J Med Chem ; 248: 115078, 2023 Feb 15.
Article in En | MEDLINE | ID: mdl-36623330
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tumor Necrosis Factor-alpha / Drug Discovery Type of study: Prognostic_studies Language: En Journal: Eur J Med Chem Year: 2023 Document type: Article Affiliation country: China Country of publication: France
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tumor Necrosis Factor-alpha / Drug Discovery Type of study: Prognostic_studies Language: En Journal: Eur J Med Chem Year: 2023 Document type: Article Affiliation country: China Country of publication: France