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Could fluoride be considered a genotoxic chemical agent in vivo? A systematic review with meta-analysis.
Drummond, Giovana Wagner Branda; Takeshita, Wilton Mitsunari; de Castro, Glaucia Monteiro; Dos Santos, Jean Nunes; Cury, Patricia Ramos; Renno, Ana Claudia Muniz; Ribeiro, Daniel Araki.
Affiliation
  • Drummond GWB; Department of Biosciences, Institute of Health and Society, Federal University of São Paulo, UNIFESP, Santos, SP, Brazil.
  • Takeshita WM; Department of Diagnosis and Surgery, School of Dentistry, São Paulo State University, UNESP, Araçatuba, SP, Brazil.
  • de Castro GM; Department of Biosciences, Institute of Health and Society, Federal University of São Paulo, UNIFESP, Santos, SP, Brazil.
  • Dos Santos JN; School of Dentistry, Federal University of Bahia, UFBA, Salvador, Brazil.
  • Cury PR; School of Dentistry, Federal University of Bahia, UFBA, Salvador, Brazil.
  • Renno ACM; Department of Biosciences, Institute of Health and Society, Federal University of São Paulo, UNIFESP, Santos, SP, Brazil.
  • Ribeiro DA; Department of Biosciences, Institute of Health and Society, Federal University of São Paulo, UNIFESP, Santos, SP, Brazil.
Int J Environ Health Res ; 34(3): 1328-1341, 2024 Mar.
Article in En | MEDLINE | ID: mdl-36994717
The goal of this study was to perform systematic review (SR) to investigate the scientific literature regarding the genotoxicity effects of fluoride exposure (FE). The search of databases used for this study was PubMed/Medline, SCOPUS and Web of Science. The quality of included studies was assessed using the EPHPP (Effective Public Health Practice Project). A total of 20 potentially relevant studies were selected for evaluating the genotoxicity induced by fluoride. Few studies have revealed that FE induces genotoxicity. A total of 14 studies demonstrated negative results whereas 6 studies did not. After reviewing the twenty studies, 1 was classified as weak, 10 were considered moderate and 9 were considered strong, according to the EPHPP. Taken together, it has been established that genotoxicity of fluoride is limited.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA Damage / Fluorides Type of study: Systematic_reviews Language: En Journal: Int J Environ Health Res Journal subject: SAUDE AMBIENTAL Year: 2024 Document type: Article Affiliation country: Brazil Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA Damage / Fluorides Type of study: Systematic_reviews Language: En Journal: Int J Environ Health Res Journal subject: SAUDE AMBIENTAL Year: 2024 Document type: Article Affiliation country: Brazil Country of publication: United kingdom