Lapachol treats non-alcoholic fatty liver disease by modulating the M1 polarization of Kupffer cells via PKM2.

Yang, Yi; Sheng, Jian; Sheng, Yongjia; Wang, Jin; Zhou, Xiaohong; Li, Wenyan; Kong, Yun

Yang, Yi; Sheng, Jian; Sheng, Yongjia; Wang, Jin; Zhou, Xiaohong; Li, Wenyan; Kong, Yun.

Affiliation

Yang Y; The Second Affiliated Hospital of Jiaxing University, 314001, China.
Sheng J; The Second Affiliated Hospital of Jiaxing University, 314001, China. Electronic address: shengjian@jxey.com.
Sheng Y; The Second Affiliated Hospital of Jiaxing University, 314001, China.
Wang J; The Second Affiliated Hospital of Jiaxing University, 314001, China.
Zhou X; The Second Affiliated Hospital of Jiaxing University, 314001, China.
Li W; The Second Affiliated Hospital of Jiaxing University, 314001, China.
Kong Y; The Second Affiliated Hospital of Jiaxing University, 314001, China. Electronic address: wasd910@qq.com.

Int Immunopharmacol ; 120: 110380, 2023 Jul.

Article in En | MEDLINE | ID: mdl-37244116

Subject(s)

Non-alcoholic Fatty Liver Disease; Rats; Animals; Non-alcoholic Fatty Liver Disease/pathology; Kupffer Cells/metabolism; Rats, Sprague-Dawley; Liver/pathology; Diet, High-Fat

Key words

Kupffer cell; Lapachol; Lipid metabolism; M1 polarization; Non-alcoholic fatty liver disease

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Non-alcoholic Fatty Liver Disease Limits: Animals Language: En Journal: Int Immunopharmacol Journal subject: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Year: 2023 Document type: Article Affiliation country: China Country of publication: Netherlands

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