Contribution of carbohydrate-related metabolism in Herpesvirus infections.
Curr Res Microb Sci
; 4: 100192, 2023.
Article
in En
| MEDLINE
| ID: mdl-37273578
Human herpesviruses are enveloped viruses with double-stranded linear DNA genomes highly prevalent in the human population. These viruses are subdivided into three subfamilies, namely alphaherpesvirinae (herpes simplex virus type 1, HSV-1; herpes simplex virus type 2, HSV-2; and varicella-zoster virus, VZV), betaherpesvirinae (human cytomegalovirus, HCMV; human herpesvirus 6, HHV-6; and human herpesvirus 7, HHV-7) and gammaherpesvirinae (Epstein-Barr virus, EBV; and Kaposi's sarcoma-associated herpesvirus, KSHV). Besides encoding numerous molecular determinants to evade the host antiviral responses, these viruses also modulate cellular metabolic processes to promote their replication. Here, we review and discuss existing studies describing an interplay between carbohydrate metabolism and the replication cycle of herpesviruses, altogether highlighting potentially new molecular targets based on these interactions that could be used to block herpesvirus infections.
Carbohydrate metabolism; Cytomegalovirus (CMV); Epstein-Barr virus (EBV); Gluconeogenesis; Glycolysis; Herpes simplex virus type 1 (HSV-1); Herpes simplex virus type 2 (HSV-2); Herpesviruses; Human herpesvirus 6 (HHV-6); Human herpesvirus 7 (HHV-7); Kaposi's sarcoma-associated herpesvirus (KSHV); Pentose phosphate pathway; Varicella-zoster virus (VZV)
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Curr Res Microb Sci
Year:
2023
Document type:
Article
Affiliation country:
Chile
Country of publication:
Netherlands