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Cytotoxic screening of plants from the Brazilian Atlantic Forest has led to the identification of Casearia arborea and Sorocea hilarii as sources of antitumor compounds.
Rodrigues, L A; Almeida, A A; Agrizii, A P; Pacheco, N; Carvalho, B C R; Zanatta, A C; Kohlhoff, M; Torres, C M M E; Bressan, G C; Leite, J P V.
Affiliation
  • Rodrigues LA; Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil.
  • Almeida AA; Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil.
  • Agrizii AP; Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil.
  • Pacheco N; Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil.
  • Carvalho BCR; Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil.
  • Zanatta AC; Universidade Estadual Paulista (Unesp), Instituto de Química, Araraquara, São Paulo, Brazil.
  • Kohlhoff M; Rene Rachou Research Center, Fiocruz, Belo Horizonte, Minas Gerais, Brazil.
  • Torres CMME; Departamento de Engenharia Florestal, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil.
  • Bressan GC; Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil.
  • Leite JPV; Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil.
Nat Prod Res ; : 1-6, 2023 Jun 27.
Article in En | MEDLINE | ID: mdl-37367484
In the present study, we have evaluated the cytotoxic activity of 282 extracts from 72 native plant species of the Brazilian Atlantic Forest biome. As a result, Casearia arborea and Sorocea hilarii leaves extracts showed cytotoxic activity against three tumour cell lines tested (B16F10, SW480 and Jurkat). After bioassay-guided fractionation, the bioactive fractions were submitted to the dereplication study via High-performance Liquid Chromatography, connected to High-resolution Mass Spectrometry (HPLC-ESI-QTOF/MS) analysis, combined with a Global Natural Products Social Molecular Networking (GNPS) tool. A combination of bioactivity-guided and dereplication approaches resulted in the putative annotation of 27 clerodane diterpenes and 9 flavonoids as main compounds present in the cytotoxic fractions of C. arborea. Regarding the active fraction of S. hilarii, 10 megastigmans, 17 spirostane steroids derivatives and 2 lignans were putatively identified. In conclusion, Casearia arborea and Sorocea hilarii are potential sources of antitumor compounds.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Diagnostic_studies / Screening_studies Country/Region as subject: America do sul / Brasil Language: En Journal: Nat Prod Res Year: 2023 Document type: Article Affiliation country: Brazil Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Diagnostic_studies / Screening_studies Country/Region as subject: America do sul / Brasil Language: En Journal: Nat Prod Res Year: 2023 Document type: Article Affiliation country: Brazil Country of publication: United kingdom